Choi Seunghyeok, Lee Hanbi, Eum Sang Hun, Min Ji-Won, Yoon Hye Eun, Yang Chul Woo, Chung Byung Ha
Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Infect Chemother. 2023 Dec;55(4):505-509. doi: 10.3947/ic.2023.0083.
We reviewed 24 kidney transplantat recipients (KTRs) who had radiologically confirmed coronavirus disease 2019 (COVID-19) pneumonia. Enrolled KTRs were divided into a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-vaccination (+) group (n = 18) and a vaccination (-) group (n = 6). Clinical outcomes of the two groups including death, pulmonary outcome, and renal outcome were compared. COVID-19 pneumonia was worse in vaccination (-) KTRs. Two out of six vaccination (-) KTRs needed continuous renal replacement therapy (CRRT) and mechanical ventilator (MV) and expired. In contrast, only one KTR expired and required CRRT and MV out of 18 vaccination (+) KTRs. Our results suggest that SARS-CoV-2 vaccination attenuates severity of COVID-19 pneumonia in KTRs.
我们回顾了24例经放射学确诊为2019冠状病毒病（COVID-19）肺炎的肾移植受者（KTRs）。纳入的KTRs被分为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗接种（+）组（n = 18）和疫苗接种（-）组（n = 6）。比较了两组的临床结局，包括死亡、肺部结局和肾脏结局。疫苗接种（-）的KTRs的COVID-19肺炎病情更严重。6例疫苗接种（-）的KTRs中有2例需要持续肾脏替代治疗（CRRT）和机械通气（MV）并死亡。相比之下，18例疫苗接种（+）的KTRs中只有1例死亡，且需要CRRT和MV。我们的结果表明，SARS-CoV-2疫苗接种可减轻KTRs中COVID-19肺炎的严重程度。
