氯法齐明对麻风病患者中利福平及氨苯砜药代动力学的影响。
The effect of clofazimine on the pharmacokinetics of rifampicin and dapsone in leprosy.
作者信息
Venkatesan K, Mathur A, Girdhar B K, Bharadwaj V P
出版信息
J Antimicrob Chemother. 1986 Dec;18(6):715-8. doi: 10.1093/jac/18.6.715.
PMID:3818497
Abstract
Fifteen untreated leprosy patients were given rifampicin and dapsone for seven days, and then rifampicin, dapsone and clofazimine for seven days. Concentrations of rifampicin and dapsone were estimated in timed plasma specimens and in 24 h urine specimens on days 7 and 14. No significant differences in the pharmacokinetics of rifampicin and dapsone were observed between the two occasions of sampling.
摘要
15名未经治疗的麻风病患者先接受7天的利福平与氨苯砜治疗，然后接受7天的利福平、氨苯砜和氯法齐明治疗。在第7天和第14天采集定时血浆标本和24小时尿液标本，测定其中利福平和氨苯砜的浓度。两次采样时利福平和氨苯砜的药代动力学未观察到显著差异。
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