Wang Yi-Nan, Shi Meng-Meng, Zhang Jin-Ming
Department of Dermatology, Yantai Hospital of Traditional Chinese Medicine, Yantai 264000, Shandong Province, China.
Department of Geriatrics, Yantai Traditional Chinese Medicine Hospital, Yantai 264000, Shandong Province, China.
World J Psychiatry. 2023 Dec 19;13(12):1037-1045. doi: 10.5498/wjp.v13.i12.1037.
Western medicine is beneficial for the recovery of neurological function in patients with depression, but some patients experience side effects such as headaches, dizziness, nausea, gastrointestinal symptoms, insomnia, and cardiac dysfunction. In recent years, integrative medicine has achieved positive results in the treatment of various diseases.
To study Chuanjin Qinggan decoction combined with selective serotonin reuptake inhibitors (SSRIs) in patients with herpes zoster complicated by depression.
Patients with herpes zoster complicated by depression who were treated at the Yantai Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were retrospectively selected as research participants. Among them, 43 patients with herpes zoster complicated by depression who received SSRI treatment between January and December 2021 were assigned to the Western medicine group, while those who received combined treatment of traditional Chinese and Western medicine between January and December 2022 were assigned to the combined group. Both groups were treated for eight weeks. The degree of pain, effect of herpes zoster treatment, degree of improvement in depressive symptoms, serum neurotransmitter levels, sleep quality, and occurrence of adverse reactions were compared between the two groups.
We found that after eight weeks of drug treatment, the two treatment schemes achieved differing efficacy. In further comparison, we found that, compared with patients treated with SSRIs alone, patients treated with Chuanjin Qinggan decoction combined with SSRIs showed more significant improvement in depression and a greater increase in dopamine and 5-hydroxytryptamine levels after treatment ( < 0.05). Patients treated with Chuanjin Qinggan decoction combined with SSRIs also experienced lower pain, better treatment efficacy for herpes zoster, better sleep quality, and a lower incidence of adverse reactions compared to those treated with SSRIs alone ( < 0.05). All minor adverse reactions occurring during treatment were resolved after symptomatic treatment.
The treatment scheme of Chuanjin Qinggan decoction combined with SSRIs can improve the psychological state of patients with herpes zoster complicated by depression and alleviate adverse reactions.
西医对抑郁症患者神经功能的恢复有益，但部分患者会出现头痛、头晕、恶心、胃肠道症状、失眠及心脏功能障碍等副作用。近年来，中西医结合医学在多种疾病的治疗中取得了积极成果。
研究穿金清肝汤联合选择性5-羟色胺再摄取抑制剂（SSRIs）治疗带状疱疹合并抑郁症患者的效果。
回顾性选取2021年1月至2022年12月在烟台市中医医院接受治疗的带状疱疹合并抑郁症患者作为研究对象。其中，2021年1月至12月接受SSRIs治疗的43例带状疱疹合并抑郁症患者被分配至西医组，2022年1月至12月接受中西医结合治疗的患者被分配至联合组。两组均治疗8周。比较两组患者的疼痛程度、带状疱疹治疗效果、抑郁症状改善程度、血清神经递质水平、睡眠质量及不良反应发生情况。
我们发现，经过8周的药物治疗，两种治疗方案的疗效有所不同。进一步比较发现，与单纯接受SSRIs治疗的患者相比，穿金清肝汤联合SSRIs治疗的患者抑郁症状改善更显著，治疗后多巴胺和5-羟色胺水平升高幅度更大（<0.05）。与单纯接受SSRIs治疗的患者相比，穿金清肝汤联合SSRIs治疗的患者疼痛程度更低，带状疱疹治疗效果更好，睡眠质量更佳，不良反应发生率更低（<0.05）。治疗期间出现的所有轻微不良反应经对症治疗后均得到缓解。
穿金清肝汤联合SSRIs的治疗方案可改善带状疱疹合并抑郁症患者的心理状态，减轻不良反应。
