Alsubai Abdulla K, Ahmad Mushtaq, Chang Rabia, Asghar Mustafa A, Siddiqui Amna, Khan Hamza N, Ashraf Muhammad H, Javaid Muhammad D, Kalwar Asifa, Asad Mahnoor, Memon Kainat, Khan Laibah A, Noorani Amber, Siddiqi Ahmed K
Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Department of Medicine, Ziauddin University, Karachi, Pakistan.
J Family Med Prim Care. 2023 Nov;12(11):2805-2826. doi: 10.4103/jfmpc.jfmpc_684_23. Epub 2023 Nov 21.
Preterm birth is linked to various complications in both infancy and adulthood. We assessed the association between preterm birth and hypertension in adulthood.
PubMed, EMBASE, and Cochrane CENTRAL Register were searched for randomized controlled trials (RCT) comparing systolic and diastolic blood pressures in individuals born preterm and those born full-term, from inception till April 11, 2022. Data were extracted, pooled, and analyzed. Forest plots were created for a visual demonstration.
Twenty-eight studies were included in our meta-analysis. SBP and DBP across all categories (Mean, Ambulatory, Daytime, and Nighttime) were higher in the preterm group compared to the term group. Mean SBP, mean ambulatory SBP, mean daytime SBP and mean nighttime SBP were 4.26 mmHg [95% CI: 3.09-5.43; < 0.00001], 4.53 mmHg [95% CI: 1.82-7.24; = 0.001], 4.51 mmHg [95% CI: 2.56-6.74; < 0.00001], and 3.06 mmHg [95% CI: 1.32-4.80; = 0.0006] higher in the preterm group, respectively. Mean DBP, mean ambulatory DBP, mean daytime DBP, and mean nighttime DBP were 2.32 mmHg [95% CI: 1.35-3.29; < 0.00001], 1.54 mmHg [95% CI 0.68-2.39; = 0.0004], 1.74 mmHg [95% CI: 0.92-2.56; < 0.0001], and 1.58 mmHg [95% CI: 0.34-2.81; = 0.01] higher in the preterm group, respectively.
Our observations suggest that individuals who were born preterm may have higher blood pressures as compared to those who were born full-term.
早产与婴儿期和成年期的各种并发症相关。我们评估了早产与成年期高血压之间的关联。
检索了PubMed、EMBASE和Cochrane CENTRAL Register数据库，以查找比较早产个体和足月出生个体的收缩压和舒张压的随机对照试验（RCT），检索时间从数据库建立至2022年4月11日。提取、汇总并分析数据。绘制森林图以便直观展示。
我们的荟萃分析纳入了28项研究。与足月组相比，早产组所有类别（平均、动态、日间和夜间）的收缩压和舒张压均更高。早产组的平均收缩压、平均动态收缩压、平均日间收缩压和平均夜间收缩压分别高出4.26 mmHg [95% CI：3.09 - 5.43；P < 0.00001]、4.53 mmHg [95% CI：1.82 - 7.24；P = 0.001]、4.51 mmHg [95% CI：2.56 - 6.74；P < 0.00001]和3.06 mmHg [95% CI：1.32 - 4.80；P = 0.0006]。早产组的平均舒张压、平均动态舒张压、平均日间舒张压和平均夜间舒张压分别高出2.32 mmHg [95% CI：1.35 - 3.29；P < 0.00001]、1.54 mmHg [95% CI 0.68 - 2.39；P = 0.0004]、1.74 mmHg [95% CI：0.92 - 2.56；P < 0.0001]和1.58 mmHg [95% CI：0.34 - 2.81；P = 0.01]。
我们的观察结果表明，与足月出生的个体相比，早产个体的血压可能更高。
