工程化皮肤微生物群减少蚊子对小鼠的吸引力。

Engineered Skin Microbiome Reduces Mosquito Attraction to Mice.

作者信息

Liu Feng, Coutinho-Abreu Iliano V, Raban Robyn, Nguyen Tam Thuy Dan, Dimas Alejandra R, Merriman Joseph A, Akbari Omar S

出版信息

bioRxiv. 2023 Dec 21:2023.12.20.572663. doi: 10.1101/2023.12.20.572663.

DOI:10.1101/2023.12.20.572663

PMID:38187765

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10769399/

Abstract

UNLABELLED

The skin microbiome plays a pivotal role in the production of attractive cues detected by mosquitoes. Here we leveraged recent advances in genetic engineering to significantly reduce the production of L-(+)-lactic acid as a strategy to reduce mosquito attraction to the highly prominent skin commensals and . Engraftment of these engineered bacteria onto the skin of mice reduced mosquito attraction and feeding for up to 11 uninterrupted days, which is considerably longer than the several hours of protection conferred by the leading chemical repellent DEET. Taken together, our findings demonstrate engineering the skin microbiome to reduce attractive volatiles represents an innovative untapped strategy to reduce vector attraction, preventing bites, and pathogen transmission setting the stage for new classes of long-lasting microbiome-based repellent products.

ONE-SENTENCE SUMMARY: Modified microbes make skin less attractive to mosquitoes.

摘要

未标记

皮肤微生物群在蚊子检测到的吸引线索的产生中起关键作用。在这里，我们利用基因工程的最新进展，大幅减少L-(+)-乳酸的产生，以此作为减少蚊子对高度突出的皮肤共生菌的吸引力的策略。将这些工程细菌移植到小鼠皮肤上，可减少蚊子的吸引力和叮咬，长达11天不间断，这比领先的化学驱避剂避蚊胺提供的数小时保护时间长得多。综上所述，我们的研究结果表明，改造皮肤微生物群以减少吸引性挥发物是一种创新的未开发策略，可减少病媒吸引力、防止叮咬和病原体传播，为新型长效微生物群驱避产品奠定基础。