Bjørke-Monsen Anne-Lise, Ueland Per Magne
Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
Food Nutr Res. 2023 Dec 26;67. doi: 10.29219/fnr.v67.10258. eCollection 2023.
Folate is an essential micronutrient for normal development and metabolic function, and folate deficiency is associated with an increased risk of cancer, cardiovascular disease, mental dysfuntion and negative pregnancy outcomes. When estimating folate requirements, one must consider different bioavailability and functionality between synthetic folic acid and dietary folate, together with increased needs of folate in women of fertile age, pregnant and lactating women, preterm and small for gestational age weight infants and individuals who are homozygote for the 5,10-methylenetetrahydrofolate reductase () gene polymorphism. In order to achieve an adequate metabolic status based on the metabolic marker total homocysteine, and not merely the absence of clinical signs of folate deficiency, the recommended intake of folate differs according to age, pregnancy and lactation. According to the World Health Organization, a decision limit for folate deficiency in adults is serum folate level below 10 nmol/L, and in women of fertile age a red blood cell folate level below 906 nmol/L in order to prevent neural tube defects. Qualified systematic reviews along with identified relevant literature have been used for this scoping review prepared for the Nordic Nutrition Recommendations 2023.
叶酸是正常发育和代谢功能所必需的微量营养素,叶酸缺乏与癌症、心血管疾病、精神功能障碍及不良妊娠结局风险增加相关。在估算叶酸需求量时,必须考虑合成叶酸与膳食叶酸之间不同的生物利用度和功能,以及育龄妇女、孕妇和哺乳期妇女、早产和小于胎龄儿及5,10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性纯合子个体对叶酸的需求增加。为了基于代谢标志物总同型半胱氨酸达到充足的代谢状态,而不仅仅是没有叶酸缺乏的临床体征,叶酸的推荐摄入量因年龄、妊娠和哺乳情况而异。根据世界卫生组织的标准,成人体内叶酸缺乏的判定界限是血清叶酸水平低于10 nmol/L,育龄妇女红细胞叶酸水平低于906 nmol/L,以预防神经管缺陷。为《2023年北欧营养建议》编写的这份范围综述采用了高质量的系统评价以及已识别的相关文献。