脱敏患者运动激发试验期间外周嗜碱性粒细胞活化的评估。
Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients.
作者信息
Kunizaki Jun, Sugiura Shiro, Sakai Akira, Teshigawara Miyuki, Makino Atsushi, Takasato Yoshihiro, Matsui Teruaki, Kondo Yasuto, Ito Komei
机构信息
Department of Allergy, Allergy and Immunology Center, Aichi Children's Health and Medical Center, Obu, Japan.
Department of Pediatrics, NTT East Sapporo Hospital, Sapporo, Japan.
出版信息
Front Allergy. 2023 Dec 22;4:1298137. doi: 10.3389/falgy.2023.1298137. eCollection 2023.
Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.
一些接受口服免疫疗法的食物过敏患者在脱敏过程中会出现运动诱发的过敏反应（EIARDs）。本研究调查了在用于诊断EIARD的运动激发试验（EPT）期间嗜碱性粒细胞的活化状态。对20名参与者进行了EPT，并使用活化标志物CD203c和CD63分析嗜碱性粒细胞的活化状态。结果表明，在整个EPT过程中，EPT阳性和阴性受试者的嗜碱性粒细胞活化状态没有显著差异。因此，摄入致敏食物后嗜碱性粒细胞的活化可能与EIARDs无关。需要新的测试来预测EIARDs。
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