一种肝素结合生长因子对神经元发育的多种影响。
Multiple influences of a heparin-binding growth factor on neuronal development.
作者信息
Schubert D, Ling N, Baird A
出版信息
J Cell Biol. 1987 Mar;104(3):635-43. doi: 10.1083/jcb.104.3.635.
Abstract
Heparin-binding growth factor-2 (HBGF-2; also known as basic fibroblast growth factor) is mitogenic for most anchorage-dependent cells. It is shown here that HBGF-2 stimulates cell-substratum adhesion and neurite extension in the sympathetic nerve cell line PC12. When HBGF-2 is adsorbed to artificial extracellular matrices consisting of heparin or chondroitin sulfate, it causes the formation of cellular aggregates or circles of cells, respectively. HBGF-2 is also a nerve cell survival molecule, for it potentiates the survival of primary cultures of embryonic chick ciliary ganglion cells but not of embryonic neural retina cells. Finally, a series of synthetic peptides from the HBGF-2 sequence is described that selectively alter the biological effects of HBGF-2. The amphiphilic nature of one of these peptides is discussed with respect to its ability to stimulate cell adhesion.
摘要
肝素结合生长因子-2（HBGF-2；也称为碱性成纤维细胞生长因子）对大多数锚定依赖性细胞具有促有丝分裂作用。本文表明，HBGF-2可刺激交感神经细胞系PC12中的细胞-基质黏附及神经突延伸。当HBGF-2吸附到由肝素或硫酸软骨素组成的人工细胞外基质上时，分别会导致细胞聚集体或细胞环的形成。HBGF-2也是一种神经细胞存活分子，因为它能增强胚胎鸡睫状神经节细胞原代培养物的存活，但对胚胎神经视网膜细胞则无此作用。最后，描述了一系列来自HBGF-2序列的合成肽，它们可选择性改变HBGF-2的生物学效应。其中一种肽的两亲性就其刺激细胞黏附的能力进行了讨论。
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