Al-Oudah Nourah, Alanazi Sara, Alotaibi Sarah Saad, Alzahrani Nayef
Department of Pathology and Laboratory Medicine, King Abdul-Aziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Department of Surgery, King Abdul-Aziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Case Rep Pathol. 2023 Dec 29;2023:7839846. doi: 10.1155/2023/7839846. eCollection 2023.
The report outlines a case of synovial sarcoma in the scrotal region. A 36-year-old male presented with a scrotal swelling. The lesion was completely resected, whereas the histopathologic examination revealed a spindle cell tumor. The tumor stained positive for pancytokeratin, AE1/AE3, epithelial membrane antigen (EMA), TLE-1, CD99, and BCL-2. The cytogenetic testing showed a chromosomal translocation in the SS18 gene at 18q11.2, consistent with the diagnosis of primary synovial sarcoma. A year later, the patient developed liver, vertebrae, and lung metastasis, which was treated with systemic chemotherapy. Treatment failed to improve the hepatic lesion that was then resected, while the spine and lung lesions were followed by radiotherapy. The patient is now alive and subject to an outstanding follow-up.
该报告概述了一例阴囊区域的滑膜肉瘤病例。一名36岁男性出现阴囊肿胀。病变被完整切除，而组织病理学检查显示为梭形细胞瘤。该肿瘤对全细胞角蛋白、AE1/AE3、上皮膜抗原（EMA）、TLE-1、CD99和BCL-2呈阳性染色。细胞遗传学检测显示18q11.2处的SS18基因发生染色体易位，符合原发性滑膜肉瘤的诊断。一年后，患者出现肝、椎骨和肺转移，接受了全身化疗。治疗未能改善肝脏病变，随后进行了肝脏病变切除术，而脊柱和肺部病变则接受了放射治疗。患者目前存活，正在接受密切随访。
