Moody D J, Kagan J, Liao D, Ellison G W, Myers L W
J Neuroimmunol. 1987 Mar;14(2):161-73. doi: 10.1016/0165-5728(87)90050-6.
Eleven patients with chronic progressive multiple sclerosis received monthly pulses of cyclophosphamide (CY) for approximately one year. During the final 9 months the monthly dose ranged between 1000 mg/m2 and 2000 mg/m2. This resulted in a marked (47% or greater) reduction in CD4 (T helper/inducer) cells a less striking (22%) decrease in CD8 (T suppressor/cytotoxic) cells and a decline in the CD4/CD8 ratio. The magnitude of the decrease in CD4 cells correlated with the total dose received (r = 0.88, P less than 0.05). B cells were reduced 50% and FcR+ lymphocytes were reduced 48% without comparable reduction in natural killer cells or antibody-dependent cellular cytotoxicity. Proliferative responses to PHA were suppressed. Two patients improved, seven stabilized and two continued to worsen. Monthly pulses of CY can achieve substantial and differential reduction in immune parameters and appear to slow the disease progression in some MS patients.
11例慢性进行性多发性硬化患者接受了约一年的每月一次环磷酰胺（CY）冲击治疗。在最后9个月中，每月剂量在1000mg/m²至2000mg/m²之间。这导致CD4（T辅助/诱导）细胞显著减少（47%或更多），CD8（T抑制/细胞毒性）细胞减少不那么明显（22%），CD4/CD8比值下降。CD4细胞减少的幅度与接受的总剂量相关（r = 0.88，P < 0.05）。B细胞减少50%，FcR +淋巴细胞减少48%，而自然杀伤细胞或抗体依赖性细胞毒性没有相应减少。对PHA的增殖反应受到抑制。2例患者病情改善，7例稳定，2例继续恶化。每月一次CY冲击治疗可使免疫参数大幅且有差异地降低，并且似乎能减缓一些MS患者的疾病进展。
