氩气吸入对光化学诱导大鼠缺血性脑卒中模型的神经保护作用。
Positive Neuroprotective Effect of Argon Inhalation after Photochemically Induced Ischemic Stroke Model in Rats.
机构信息
A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2023 Dec;176(2):143-149. doi: 10.1007/s10517-024-05984-6. Epub 2024 Jan 8.
We studied the effect of 2-h inhalation of argon-oxygen mixture (Ar 70%/O 30%) after photochemically induced stroke and on days 2 and 3 after stroke modeling on the severity of neurological deficit and brain damage (by MRI data) in Wistar rats. Neurological deficit was assessed within 14 days using the limb placement test. MRI and histological study of the brain with an assessment of the size of damage were performed on day 14 after ischemia. Significant differences were obtained in limb placement scores on days 3, 7, and 14, as well as in the volume of ischemic focus by MRI in comparison with the control (ischemia+N 70%/O 30%). Inhalation of argon-oxygen mixture for 2 h a day over 3 days after photoinduced stroke decreased the volume of brain damage by 2 times and reduced the severity of neurological deficit.
我们研究了光化学诱导中风后吸入 2 小时的氩-氧混合气体（Ar70%/O30%）以及中风模型建立后第 2 天和第 3 天对 Wistar 大鼠的神经功能缺损严重程度和脑损伤（基于 MRI 数据）的影响。在 14 天内使用肢体放置测试评估神经功能缺损。在缺血后第 14 天进行 MRI 和脑组织学研究，并评估损伤的大小。与对照组（缺血+N70%/O30%）相比，在第 3、7 和 14 天的肢体放置评分以及 MRI 显示的缺血灶体积上均获得了显著差异。吸入氩-氧混合气体每天 2 小时，持续 3 天，可使脑损伤体积减少 2 倍，并降低神经功能缺损的严重程度。
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