Pozdniakov V I, Pankov Iu A
Mol Biol (Mosk). 1979 Jul-Aug;13(4):899-911.
A computing method for calculation of total similarity of two amino acid sequences depending on the number of gaps introduced into these sequences has been developed. It was based on Needleman--Wunsch--Sankoff's principles. The application of the method to randomized sequences enables us to select the optimal alignment of real sequences, in which the number of gaps is statistically justified. In this paper an example of the application of this approach is described and the statistically optimal alignment of somatotropin and prolactin amino acid sequences with two gaps is suggested.
已经开发出一种根据引入两个氨基酸序列中的空位数量来计算这两个氨基酸序列总相似度的计算方法。它基于尼德曼-翁施-桑科夫原理。将该方法应用于随机序列使我们能够选择真实序列的最佳比对，其中空位数量具有统计学依据。本文描述了这种方法的应用实例，并提出了生长激素和催乳素氨基酸序列带有两个空位的统计学最优比对。
