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门诊脊髓损伤患者尿路感染的抗生素药敏数据。

Antibiogram data of urinary tract infection in spinal cord injury patients in an outpatient setting.

机构信息

From the Functional Care Services, Department of Rehabilitation Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

出版信息

Neurosciences (Riyadh). 2024 Jan;29(1):57-62. doi: 10.17712/nsj.2024.1.20230063.

DOI:10.17712/nsj.2024.1.20230063
PMID:38195136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10827016/
Abstract

OBJECTIVES

To establish antibiogram data for patients with spinal cord injury (SCI) that would help differentiate the organisms commonly present depending on the voiding method and antibiotic sensitivity for empirical treatment.

METHODS

A total of 499 urine culture results were obtained from 151 SCI patients with symptomatic urinary tract infection (UTI) with significant bacteriuria and pyuria with more than 10 white blood cells per high power field. The voiding method was categorized as follows: self-intermittent catheterization (SIC), suprapubic catheter (SPC), Foley catheter, condom catheter, or voiding freely.

RESULTS

The demographic data were as follows: male, n=124 (82.2%); female, n=27 (17.8%); mean age, 39; paraplegic n=105 (69.5%); and tetraplegic, n=45 (29.8%). The SIC was the most common voiding method (n=64, 42.3%), followed by Foley catheter (n=39, 25.8%). Escherichia coli was the most common organism overall (29%) and more frequent in patients using SIC as the voiding method. was present more frequently in patients using SPC (33%), and in voiding freely cultures (30%). Antibiotic sensitivity was as follows Gentamicin (44.1%), Nitrofurantoin (39.1%), Augmentin (33.5%), and Ciprofloxacin (31.5%).

CONCLUSION

Increased preference of the local population to foley catheter as a voiding method which needs to be investigated more. The type of voiding methods in patients with SCI results in different common causative organisms of UTI. Ciprofloxacin resistance profile increased overall except in patients voiding with SPC. Nitrofurantoin is the most overall sensitive oral antibiotic in our sample followed by Augmentin then Cefuroxime.

摘要

目的

建立脊髓损伤(SCI)患者的抗生素药敏数据,帮助根据排尿方式和经验性治疗的抗生素敏感性来区分常见的病原体。

方法

对 151 例有症状性尿路感染(UTI)、有大量细菌和脓尿且高倍镜下白细胞超过 10 个的 SCI 患者的 499 份尿培养结果进行了研究。排尿方式分为以下几类:自我间歇性导尿(SIC)、耻骨上导管(SPC)、 Foley 导管、避孕套导管和自由排尿。

结果

人口统计学数据如下:男性,n=124(82.2%);女性,n=27(17.8%);平均年龄 39 岁;截瘫,n=105(69.5%);四肢瘫,n=45(29.8%)。SIC 是最常见的排尿方式(n=64,42.3%),其次是 Foley 导管(n=39,25.8%)。大肠杆菌是最常见的病原体(29%),在使用 SIC 作为排尿方式的患者中更为常见。克雷伯菌在使用 SPC 排尿的患者中更为常见(33%),在自由排尿的患者中更为常见(30%)。抗生素敏感性如下:庆大霉素(44.1%)、呋喃妥因(39.1%)、氨曲南(33.5%)和环丙沙星(31.5%)。

结论

当地居民更喜欢 Foley 导管作为排尿方式,这需要进一步调查。SCI 患者的排尿方式导致不同的 UTI 常见病原体。除了使用 SPC 排尿的患者外,环丙沙星的耐药谱总体上有所增加。在我们的样本中,呋喃妥因是最敏感的口服抗生素,其次是氨曲南,然后是头孢呋辛。

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BMC Infect Dis. 2022 Mar 9;22(1):239. doi: 10.1186/s12879-022-07235-3.
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Implementation and evaluation of an algorithm-based order set for the outpatient treatment of urinary tract infections in the spinal cord injury population in a VA Medical Center.退伍军人事务部医疗中心针对脊髓损伤人群尿路感染门诊治疗的基于算法的医嘱集的实施与评估
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