Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Korea.
Kangnam Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
J Asthma. 2024 Aug;61(8):801-807. doi: 10.1080/02770903.2024.2303770. Epub 2024 Jan 24.
We investigated the correlation between urine VOC metabolites and airway function in children exposed to anthropogenic volatile organic compounds (VOCs), notable pollutants impacting respiratory health.
Out of 157 respondents, 141 completed skin prick tests, spirometry, IOS, and provided urine samples following the International Study of Asthma and Allergies in Childhood (ISAAC)-related questions. Allergic sensitization was assessed through skin prick tests, and airway functions were evaluated using spirometry and impulse oscillometry (IOS). Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) was recorded and FEV1/FVC ratio was calculated. Airway mechanics parameters including respiratory resistance at 5 Hz (Rrs5) mean respiratory resistance between 5 Hz and 20 Hz (Rrs5-20), were also recorded. Urine concentrations of metabolites of benzene, ethylbenzene, toluene, xylene, styrene, formaldehyde, carbon-disulfide were analyzed by gas chromatography/tandem mass spectroscopy.
The median age at study participation was 7.1 (SD 0.3) years. Muconic acid (benzene metabolites) and o-methyl-hippuric acid (xylene metabolites) above medians were associated with a significant increase in Rrs5 (muconic acid: aβ = 0.150, = .002; o-methyl-hippuric acid: aβ = 0.143, = .023) and a decrease in FEV1/FVC (o-methyl-hippuric acid: aβ = 0.054, = .028) compared to those below median. No associations were observed for Rrs5-20 and FEV1 between the groups categorized as above and below the median (all parameter values > .05).
Elevated levels of benzene and xylene metabolites were associated with a significant increase in Rrs5 and a decrease in FEV1/FVC, related to increased resistance and restrictive lung conditions compared to individuals with concentrations below the median.
我们研究了暴露于人为挥发性有机化合物（VOC）的儿童尿液 VOC 代谢物与气道功能之间的相关性，这些 VOC 是影响呼吸健康的显著污染物。
在 157 名应答者中，141 名完成了皮肤点刺试验、肺活量测定、IOS 并按照国际儿童哮喘和过敏研究（ISAAC）相关问题提供了尿液样本。过敏致敏通过皮肤点刺试验进行评估，气道功能通过肺活量测定和脉冲震荡（IOS）进行评估。记录 1 秒用力呼气量（FEV1）、用力肺活量（FVC），并计算 FEV1/FVC 比值。还记录了气道力学参数，包括 5 Hz 呼吸阻力（Rrs5）、5 Hz 与 20 Hz 之间的平均呼吸阻力（Rrs5-20）。通过气相色谱/串联质谱法分析尿液中苯、乙苯、甲苯、二甲苯、苯乙烯、甲醛、二硫化碳代谢物的浓度。
研究参与时的中位数年龄为 7.1（SD 0.3）岁。马尿酸（苯代谢物）和邻-甲基-马尿酸（二甲苯代谢物）高于中位数与 Rrs5 显著增加相关（马尿酸：aβ=0.150，=0.002；邻-甲基-马尿酸：aβ=0.143，=0.023），与 FEV1/FVC 降低相关（邻-甲基-马尿酸：aβ=0.054，=0.028），与中位数以下者相比。两组（高于和低于中位数）之间 Rrs5-20 和 FEV1 之间无关联（所有参数值均>0.05）。
与中位数以下浓度相比，苯和二甲苯代谢物水平升高与 Rrs5 显著增加和 FEV1/FVC 降低相关，表明阻力增加和限制性肺部状况。
