Institut Curie, département d'oncologie radiothérapie, Paris, France.
Institut Curie, département d'oncologie radiothérapie, Paris, France.
Bull Cancer. 2024 Mar;111(3):310-313. doi: 10.1016/j.bulcan.2023.11.010. Epub 2024 Jan 9.
Ophthalmic lymphomas, a subgroup of extra-nodal lymphomas, have seen an increase in incidence in recent decades. Of these, the NK/T-cell lymphoma (NKTL) subtype is particularly aggressive. Though prevalent mostly in Asian patients, data on ophthalmic NKTL is still limited, especially in the western population. This study aimed to provide an additional analysis of primary ophthalmic NKTL using the Surveillance, Epidemiology, and End Results (SEER) database.
A retrospective analysis was performed on the SEER database covering records from 2000 to 2020. Patients diagnosed with extranodal NKTL originating primarily from an ophthalmic structure were identified.
Out of 4540 ophthalmic lymphomas registered in the SEER database between 2000 and 2020, 9 cases (0.2%) corresponded to ophthalmic NKTL, occurring in patients with a median age of 67 years. The majority of these patients underwent chemotherapy (88.8%) and radiotherapy (66.6%). The 6-month overall survival (OS) and cancer-specific survival (CSS) were both at 50.8%, dropping significantly at the 2-year follow-up.
Primary orbital NKTL has a notably severe prognosis. An early diagnosis is important due to the aggressive nature of NKTL.
眼附属器淋巴瘤是结外淋巴瘤的一个亚组，近年来其发病率有所上升。在这些淋巴瘤中，NK/T 细胞淋巴瘤（NKTL）亚型侵袭性特别强。虽然这种疾病主要发生在亚洲患者中，但关于眼 NKTL 的数据仍然有限，尤其是在西方人群中。本研究旨在利用监测、流行病学和最终结果（SEER）数据库对原发性眼 NKTL 进行额外分析。
对 SEER 数据库中 2000 年至 2020 年的记录进行回顾性分析，确定了最初源自眼结构的结外 NKTL 患者。
在 2000 年至 2020 年间 SEER 数据库中登记的 4540 例眼部淋巴瘤中，有 9 例（0.2%）为眼 NKTL，患者中位年龄为 67 岁。这些患者大多接受了化疗（88.8%）和放疗（66.6%）。6 个月的总生存率（OS）和癌症特异性生存率（CSS）均为 50.8%，在 2 年随访时显著下降。
原发性眼眶 NKTL 的预后明显较差。由于 NKTL 的侵袭性，早期诊断很重要。
