Gleicher N, Deppe G, Cohen C J
Obstet Gynecol. 1979 Sep;54(3):335-42.
The fetoplacental allograft and the malignant neoplasm represent the only 2 biologic conditions in which antigenic tissue is tolerated by a seemingly intact immune system. Recent investigations in the fields of tumor and pregnancy immunology have resulted in the recognition of a variety of immunologic mechanisms which are common to both systems. These common denominators are reviewed and a thesis suggesting a common mechanism in the nonrejection of pregnancy and malignancy, based on the presence of embryonic antigens in both systems, is presented.
胎儿胎盘同种异体移植和恶性肿瘤是仅有的两种生物状态，在这两种状态下，抗原性组织似乎能被完整的免疫系统所耐受。肿瘤免疫学和妊娠免疫学领域的最新研究已使人们认识到这两种系统共有的多种免疫机制。本文对这些共同特征进行了综述，并提出了一种基于两种系统中均存在胚胎抗原的关于妊娠和恶性肿瘤不被排斥的共同机制的论点。
