Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Benephyt, Strasbourg, France.
Acta Neuropsychiatr. 2024 Oct;36(5):325-329. doi: 10.1017/neu.2023.60. Epub 2024 Jan 11.
The link between cannabis use and psychotic symptoms or disorders is well known. However, the relation between cannabis withdrawal and psychotic symptoms is less studied.
To our knowledge, this is the first publication of an observational systematic report of cannabis-induced psychotic disorder with onset during withdrawal. Here, we review patients presenting to a major emergency room in Montreal between January 2020 and September 2023 in a context of psychotic symptoms following cannabis cessation.
In total, seven male and one female patients presented at the peak of cannabis withdrawal with acute psychotic symptoms, representing less than 1% of all emergency service admissions.
We discuss current knowledge regarding the endocannabinoid system and dopamine homeostasis to formulate hypotheses regarding these observations.
大麻使用与精神病症状或障碍之间的联系是众所周知的。然而，大麻戒断与精神病症状之间的关系研究较少。
据我们所知，这是第一篇关于大麻引起的精神病障碍在戒断期间发作的观察性系统报告。在这里，我们回顾了 2020 年 1 月至 2023 年 9 月期间在蒙特利尔一家主要急诊室就诊的患者，这些患者在停止使用大麻后出现了精神病症状。
共有 7 名男性和 1 名女性患者在大麻戒断高峰期出现急性精神病症状，占所有急诊服务入院人数的不到 1%。
我们讨论了当前关于内源性大麻素系统和多巴胺动态平衡的知识，以提出关于这些观察结果的假设。
