Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Cells. 2023 Dec 29;13(1):72. doi: 10.3390/cells13010072.
It has been 50 years since Peter Charles Doherty and Rolf M Zinkernagel proposed the principle of "simultaneous dual recognition", according to which adaptive immune cells recognized "self" and "non-self" simultaneously to establish immunological efficacy. These two scientists shared the 1996 Nobel Prize in Physiology or Medicine for this discovery. Their basic immunological principle became the foundation for the development of numerous vaccine approaches against infectious diseases and tumors, including promising strategies grounded on the use of recombinant gp96-Ig developed by our lab over the last two decades. In this review, we will highlight three major principles of the gp96-Ig vaccine strategy: (1) presentation of pathogenic antigens to T cells (specificity); (2) activation of innate immune responses (adjuvanticity); (3) priming of T cells to home to the epithelial compartments (mucosal immunity). In summary, we provide a paradigm for a vaccine approach that can be rapidly engineered and customized for any future pathogens that require induction of effective tissue-resident memory responses in epithelial tissues.
自 Peter Charles Doherty 和 Rolf M Zinkernagel 提出“同时双重识别”原则以来，已经过去了 50 年。根据这一原则，适应性免疫细胞同时识别“自我”和“非自我”，从而建立免疫效力。这两位科学家因这一发现共同获得了 1996 年诺贝尔生理学或医学奖。他们的基本免疫学原理为针对传染病和肿瘤的众多疫苗方法的发展奠定了基础，包括我们实验室过去二十年中基于使用重组 gp96-Ig 开发的有前途的策略。在这篇综述中，我们将重点介绍 gp96-Ig 疫苗策略的三个主要原则：（1）将病原体抗原呈递给 T 细胞（特异性）；（2）激活先天免疫反应（佐剂性）；（3）启动 T 细胞向上皮细胞区室归巢（黏膜免疫）。总之，我们为疫苗方法提供了一个范例，该范例可以针对任何未来需要在上皮组织中诱导有效组织驻留记忆反应的病原体进行快速设计和定制。
