结直肠癌肝转移的多层次异质性

Multilevel Heterogeneity of Colorectal Cancer Liver Metastasis.

作者信息

Chen Hao, Zhai Chongya, Xu Xian, Wang Haidong, Han Weidong, Shen Jiaying

机构信息

Department of Medical Oncology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.

出版信息

Cancers (Basel). 2023 Dec 21;16(1):59. doi: 10.3390/cancers16010059.

DOI:10.3390/cancers16010059

PMID:38201487

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10778489/

Abstract

Colorectal cancer liver metastasis (CRLM) is a highly heterogeneous disease. Therapies that target both primary foci and liver metastasis are severely lacking. Therefore, understanding the features of metastatic tumor cells in the liver is valuable for the overall control of CRLM patients. In this review, we summarize the heterogeneity exhibited in CRLM from five aspects (gene, transcriptome, protein, metabolism, and immunity). In addition to genetic heterogeneity, the other four aspects exhibit significant heterogeneity. Compared to primary CRC, the dysregulation of epithelial-mesenchymal transition (EMT)-related proteins, the enhanced metabolic activity, and the increased infiltration of immunosuppressive cells are detected in CRLM. Preclinical evidence shows that targeting the EMT process or enhancing cellular metabolism may represent a novel approach to increasing the therapeutic efficacy of CRLM.

摘要

结直肠癌肝转移（CRLM）是一种高度异质性疾病。严重缺乏针对原发灶和肝转移的治疗方法。因此，了解肝脏中转移瘤细胞的特征对于CRLM患者的整体控制具有重要价值。在本综述中，我们从五个方面（基因、转录组、蛋白质、代谢和免疫）总结了CRLM中表现出的异质性。除了基因异质性外，其他四个方面也表现出显著的异质性。与原发性结直肠癌相比，在CRLM中检测到上皮-间质转化（EMT）相关蛋白的失调、代谢活性增强以及免疫抑制细胞浸润增加。临床前证据表明，靶向EMT过程或增强细胞代谢可能是提高CRLM治疗效果的新方法。