Nepean Clinical School, Faculty of Medicine and Health, University of Sydney, Penrith, NSW 2751, Australia.
Charles Perkins Centre, University of Sydney, Sydney, NSW 2003, Australia.
Nutrients. 2023 Dec 29;16(1):124. doi: 10.3390/nu16010124.
Gestational diabetes mellitus (GDM) is associated with poorer maternal mental health (depression and anxiety). Maternal mental health and GDM are likely to influence diet, which in turn impacts the course of GDM. Maternal diet may also be directly or indirectly associated with changes in infant anthropometry. The aims of this study are to (1) examine the associations between maternal GDM, mental health and diet, and (2) evaluate the associations between these maternal factors, breastmilk composition and infant anthropometry.
This prospective, observational, longitudinal cohort study compares a cohort of women with and without GDM. Maternal mental health and diet are assessed using validated questionnaires. Breastmilk composition is measured with the Human Milk Analyzer, and infant body composition is measured with air displacement plethysmography.
Once data have been collected, PsyNBIOsis will provide evidence for the associations between maternal mental health, GDM status and diet, and their impact on breastmilk composition and early infant growth. The results may inform the Developmental Origins of Health and Disease framework and provide data on which to build cost-effective interventions to prevent both the development of mental health issues in mothers and adverse growth patterns in infants.
妊娠糖尿病（GDM）与产妇心理健康（抑郁和焦虑）较差有关。产妇心理健康和 GDM 可能会影响饮食，进而影响 GDM 的病程。产妇饮食也可能与婴儿体格生长的变化直接或间接相关。本研究的目的是：（1）研究 GDM、心理健康和饮食之间的关联；（2）评估这些产妇因素、母乳成分和婴儿体格生长之间的关联。
本前瞻性、观察性、纵向队列研究比较了 GDM 组和非 GDM 组。使用经过验证的问卷评估产妇的心理健康和饮食。使用人乳分析仪测量母乳成分，使用空气置换体积描记法测量婴儿的身体成分。
一旦收集到数据，PsyNBIOsis 将提供有关产妇心理健康、GDM 状况和饮食及其对母乳成分和婴儿早期生长的影响的证据。研究结果可能为健康与疾病的发育起源框架提供依据，并为制定具有成本效益的干预措施提供数据，以预防母亲心理健康问题和婴儿不良生长模式的发生。
