Takao Eri, Ichitani Aona, Tanito Masaki
Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
J Clin Med. 2023 Dec 28;13(1):184. doi: 10.3390/jcm13010184.
This study aims to report the disparity between the ideal and actual quantities of eyedrops prescribed to individual glaucoma patients. This retrospective observational study included 676 patients receiving treatment with antiglaucoma topical medication(s) in at least one eye. These patients had follow-up appointments scheduled at mean intervals of 3.4 ± 1.4 months and were actively using antiglaucoma medication. The mean age was 70.4 ± 11.9 years, with 372 (55%) being male. The over-prescription volume was 1.4 ± 1.7 bottles per month for each medication when prescribed for both eyes. Multiple regression analysis revealed that older age ( = 0.03), hyperopic refractive error ( < 0.0001), and the use of multiple medications ( = 0.03) were associated with a larger over-prescription volume, while the use of unit-dose medication only ( < 0.0001) was associated with a smaller over-prescription volume. Factors such as sex, Mini-Cog cognitive function score, best-corrected visual acuity, intraocular pressure, glaucoma type, and a history of cataract surgery were not significantly associated. This study revealed a significant over-prescription of eyedrops for glaucoma patients, with actual prescriptions often exceeding the theoretically ideal amount by 2.4 times, influenced by factors like age and the format of prescriptions, where unit-dose eyedrops show promise in reducing excess.
本研究旨在报告青光眼患者眼药水理想处方量与实际处方量之间的差异。这项回顾性观察性研究纳入了676例至少一只眼睛接受抗青光眼局部药物治疗的患者。这些患者的随访预约平均间隔为3.4±1.4个月，并且正在积极使用抗青光眼药物。平均年龄为70.4±11.9岁，其中372例（55%）为男性。每只眼睛开两种药时，每种药物的每月过量处方量为1.4±1.7瓶。多元回归分析显示，年龄较大（P = 0.03）、远视屈光不正（P < 0.0001）以及使用多种药物（P = 0.03）与较大的过量处方量相关，而仅使用单位剂量药物（P < 0.0001）与较小的过量处方量相关。性别、简易认知功能评分、最佳矫正视力、眼压、青光眼类型和白内障手术史等因素无显著相关性。本研究揭示了青光眼患者眼药水存在明显的过量处方情况，实际处方量常常比理论理想量超出2.4倍，受年龄和处方形式等因素影响，单位剂量眼药水在减少过量方面显示出前景。
