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壳聚糖介导的纳米粒子优化 DOX 药物传递及癌症化疗中的刺激响应：综述。

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review.

机构信息

Department of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.

College of Food Science and Engineering, Jilin University, Changchun 130062, China.

出版信息

Molecules. 2023 Dec 20;29(1):31. doi: 10.3390/molecules29010031.

DOI:10.3390/molecules29010031
PMID:38202616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10780101/
Abstract

Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due to its resistance and lack of specificity. Chitosan NPs have been used for DOX delivery because of their biocompatibility, biodegradability, drug encapsulation efficiency, and target specificity. In this review, various types of chitosan derivatives are discussed in DDSs to enhance the effectiveness of cancer treatments. Modified chitosan-DOX NP drug deliveries with other compounds also increase the penetration and efficiency of DOX against tumor cells. We also highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX drug delivery in cancer treatment and may inspire the development of more effective approaches for cancer chemotherapy.

摘要

壳聚糖纳米粒子（NPs）可作为癌症化疗中有用的多药物传递载体。壳聚糖在靶向肿瘤细胞的药物传递系统（DDS）中有很大的潜力。由于其耐药性和缺乏特异性，阿霉素（DOX）的应用受到限制。由于其生物相容性、生物降解性、药物包封效率和靶向特异性，壳聚糖 NPs 已被用于 DOX 的传递。在本综述中，讨论了各种类型的壳聚糖衍生物在 DDS 中以提高癌症治疗的效果。用其他化合物修饰的壳聚糖-DOX NP 药物传递也增加了 DOX 对肿瘤细胞的穿透和效率。我们还强调了内源性刺激（pH、氧化还原、酶）和外源性刺激（光、磁、超声），以及它们对通过壳聚糖 NPs 进行 DOX 药物传递的积极影响。我们的研究强调了壳聚糖 NPs 在 DOX 药物传递用于癌症治疗中的重要性，并可能激发癌症化疗中更有效方法的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/9b06fcee6f5c/molecules-29-00031-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/11a76fad93ec/molecules-29-00031-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/c9ce0f7962a4/molecules-29-00031-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/55fa766930e0/molecules-29-00031-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/4a31d57aa679/molecules-29-00031-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/d2bbf7e04866/molecules-29-00031-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/d6cbcee9a67d/molecules-29-00031-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/b3696fc38d5f/molecules-29-00031-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/9b06fcee6f5c/molecules-29-00031-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/11a76fad93ec/molecules-29-00031-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/c9ce0f7962a4/molecules-29-00031-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/55fa766930e0/molecules-29-00031-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/4a31d57aa679/molecules-29-00031-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/d2bbf7e04866/molecules-29-00031-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/d6cbcee9a67d/molecules-29-00031-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/b3696fc38d5f/molecules-29-00031-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8172/10780101/9b06fcee6f5c/molecules-29-00031-g008.jpg

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[3]
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[4]
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[5]
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[6]
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[7]
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本文引用的文献

[1]
Exploring the potential of pH-sensitive polymers in targeted drug delivery.

J Biomater Sci Polym Ed. 2024-2

[2]
Peptides as carriers of active ingredients: A review.

Curr Res Food Sci. 2023-9-17

[3]
Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment.

Cancer Lett. 2023-10-10

[4]
Synthesis of magnetic chitosan/hyaluronic acid/κ-carrageenan nanocarriers for drug delivery.

Int J Biol Macromol. 2023-12-31

[5]
Nanoparticle-based drug delivery systems to enhance cancer immunotherapy in solid tumors.

Front Immunol. 2023

[6]
Redox-sensitive self-assembled micelles based on low molecular weight chitosan-lipoic acid conjugates for the delivery of doxorubicin: Effect of substitution degree of lipoic acid.

Int J Biol Macromol. 2023-8-30

[7]
Construction of multi-program responsive vitamin E succinate-chitosan-histidine nanocarrier and its response strategy in tumor therapy.

Int J Biol Macromol. 2023-8-15

[8]
All-in-one glycol chitosan nanoparticles for co-delivery of doxorubicin and anti-PD-L1 peptide in cancer immunotherapy.

Bioact Mater. 2023-6-10

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Functionalized chitosan for cancer nano drug delivery.

Biotechnol Adv. 2023-10

[10]
Construction of carboxymethyl chitosan-based nanoparticles of hypoxia response for co-loading doxorubicin and tanshinone IIA.

Int J Biol Macromol. 2023-7-31

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