Department of Hematology and Breast Cancer, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
Second Ward of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China; The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, China.
Cancer Lett. 2023 Oct 10;574:216397. doi: 10.1016/j.canlet.2023.216397. Epub 2023 Sep 18.
Melanoma, the most aggressive form of cutaneous malignancy arising from melanocytes, is frequently characterized by metastasis. Despite considerable progress in melanoma therapies, patients with advanced-stage disease often have a poor prognosis due to the limited efficacy, off-target effects, and toxicity associated with conventional drugs. Nanotechnology has emerged as a promising approach to address these challenges with nanoparticles capable of delivering therapeutic agents specifically to the tumor microenvironment (TME). However, the clinical approval of nanomedicines for melanoma treatment remains limited, necessitating further research to develop nanoparticles with improved biocompatibility and precise targeting capabilities. This comprehensive review provides an overview of the current research on nano-drug delivery systems for melanoma treatment, focusing on liposomes, polymeric nanoparticles, and inorganic nanoparticles. It discusses the potential of these nanoparticles for targeted drug delivery, as well as their ability to enhance the efficacy of conventional drugs while minimizing toxicity. Furthermore, this review emphasizes the significance of interdisciplinary collaboration between researchers from various fields to advance the development of nanomedicines. Overall, this review serves as a valuable resource for researchers and clinicians interested in the potential of nano-drug delivery systems for melanoma treatment and offers insights into future directions for research in this field.
黑色素瘤是一种源自黑色素细胞的侵袭性最强的皮肤恶性肿瘤，常以转移为特征。尽管在黑色素瘤治疗方面取得了相当大的进展，但由于常规药物的疗效有限、脱靶效应和毒性，晚期疾病患者的预后往往较差。纳米技术已成为一种有前途的方法，可以通过能够将治疗剂专门递送到肿瘤微环境（TME）的纳米颗粒来解决这些挑战。然而，用于治疗黑色素瘤的纳米药物的临床批准仍然有限，需要进一步研究以开发具有改善的生物相容性和精确靶向能力的纳米颗粒。
这篇全面的综述概述了目前用于黑色素瘤治疗的纳米药物递送系统的研究，重点介绍了脂质体、聚合物纳米颗粒和无机纳米颗粒。它讨论了这些纳米颗粒用于靶向药物递送的潜力，以及它们增强常规药物疗效同时最小化毒性的能力。此外，本综述强调了来自不同领域的研究人员之间进行跨学科合作的重要性，以推进纳米药物的发展。
总体而言，本综述为对纳米药物递送系统治疗黑色素瘤的潜力感兴趣的研究人员和临床医生提供了有价值的资源，并为该领域的未来研究方向提供了见解。
