Department of Chemistry, Federal University of Agriculture, Abeokuta 111101, Nigeria.
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA.
Molecules. 2024 Jan 3;29(1):249. doi: 10.3390/molecules29010249.
The -phenylquinoneimine scaffold is a versatile synthetic platform that has gained significant attention in the field of drug discovery due to its structural diversity and capacity to interact with biologically relevant targets. This review explores established synthetic methodologies and highlights the significant biological activities exhibited by compounds derived from this scaffold, their implications for medicinal chemistry, and the development of novel therapeutics.
-phenylquinoneimine 支架是一种多功能的合成平台，由于其结构多样性和与生物相关靶标的相互作用能力，在药物发现领域引起了广泛关注。本综述探讨了已建立的合成方法，并强调了源自该支架的化合物所表现出的显著生物学活性、它们对药物化学的意义以及新型治疗药物的开发。
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