Almeida Renata G, Valença Wagner O, Rosa Luísa G, de Simone Carlos A, de Castro Solange L, Barbosa Juliana M C, Pinheiro Daniel P, Paier Carlos R K, de Carvalho Guilherme G C, Pessoa Claudia, Goulart Marilia O F, Kharma Ammar, da Silva Júnior Eufrânio N
Institute of Exact Sciences , Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte , 31270-901 , MG , Brazil . Email:
Center for the Development of Chemical Technologies , State University of Mato Grosso do Sul , Naviraí , 79950-000 , MS , Brazil.
RSC Med Chem. 2020 Jul 13;11(10):1145-1160. doi: 10.1039/d0md00072h. eCollection 2020 Oct 1.
-Quinones represent a special class of redox active compounds associated with a spectrum of pronounced biological activities, including selective cytotoxicity and antimicrobial actions. The modification of the quinone ring by simple nitrogen and sulphur substitutions leads to several new classes of compounds with their own, distinct redox behaviour and equally distinct activities against cancer cell lines and . Some of the compounds investigated show activity against at concentrations of 24.3 and 65.6 μM with a selectivity index of around 1. These results demonstrate that simple chemical modifications on the -quinone ring system, in particular, by heteroatoms such as nitrogen and sulphur, transform these simple redox molecules into powerful cytotoxic agents with considerable "potential", not only in synthesis and electrochemistry, but also, in a broader sense, in health sciences.
醌类是一类特殊的氧化还原活性化合物，具有一系列显著的生物活性，包括选择性细胞毒性和抗菌作用。通过简单的氮和硫取代对醌环进行修饰，可产生几类新的化合物，它们具有各自独特的氧化还原行为，以及对癌细胞系同样独特的活性。一些研究的化合物在浓度为24.3和65.6 μM时对[具体对象未提及]显示出活性，选择性指数约为1。这些结果表明，特别是通过氮和硫等杂原子对醌环系统进行简单的化学修饰，可将这些简单的氧化还原分子转化为具有相当“潜力”的强大细胞毒性剂，不仅在合成和电化学方面，而且从更广泛的意义上讲，在健康科学领域也是如此。
