皮肤涂抹久效磷-92（工业级）对白化大鼠不同组织和血液生化参数的影响。

Effect of dermal application of phosphamidon-92 (technical) on different tissues and hematobiochemical parameters in albino rat.

作者信息

Qadri S S, Usha G, Jabeen K, Rahman M F, Mustafa M

出版信息

J Toxicol Environ Health. 1987;20(3):273-86. doi: 10.1080/15287398709530981.

PMID:3820340

Abstract

The histological disturbances occurring from the dermal application of low, medium, and high doses of phosphamidon-92 (technical) to rats as observed by light microscope and analysis of hematobiochemical parameters of blood are presented. Groups of 10 male and 10 female albino rats (Wistar strain) were treated with the test material at dose levels of 0.48 (low), 2.2 (medium), and 3.98 (high) mg/kg X d for 3 wk, followed by a 2-wk observation period. During application, a reduction in food intake and in body weight was recorded with all three treatments. However, gain in body weight and food intake resumed during the observation period and was marked with the high-dose treatment only. Symptoms like hypersalivation and frothing were noticed in both the sexes, as well as a relative decrease in liver weight and gross pathological alterations on microscopical examination of skin, lung, kidney, and testis; significant alterations in some hematobiochemical parameters of blood were observed.

摘要

本文呈现了通过光学显微镜观察以及对大鼠血液血液生化参数进行分析，来研究经皮肤给大鼠涂抹低、中、高剂量的久效磷-92（工业品）后所产生的组织学紊乱情况。将10只雄性和10只雌性白化大鼠（Wistar品系）分为一组，分别用剂量为0.48（低）、2.2（中）和3.98（高）mg/kg×d的受试物质处理3周，随后进行2周的观察期。在给药期间，所有三种处理方式均记录到食物摄入量和体重下降。然而，在观察期内体重增加和食物摄入量恢复，且仅在高剂量处理组有明显变化。在雌雄两性中均观察到流涎和吐白沫等症状，以及肝脏重量相对减轻，皮肤、肺、肾和睾丸的显微镜检查出现大体病理改变；同时观察到血液中一些血液生化参数有显著变化。