Systematic Multiomic Analysis of Gene Expression and Its Role as a Predicting Biomarker for Immune Cell Infiltration in Skin Cutaneous Melanoma and Lung Adenocarcinoma.

The identification of genetic factors that regulate the cancer immune microenvironment is important for understanding the mechanism of tumor progression and establishing an effective treatment strategy. Polycystic kidney and hepatic disease 1-like protein 1 (PKHD1L1) is a large transmembrane protein that is highly expressed in immune cells; however, its association with tumor progression remains unclear. Here, we systematically analyzed the clinical relevance of in the tumor microenvironment in multiple cancer types using various bioinformatic tools. We found that the mRNA expression levels were significantly lower in skin cutaneous melanoma (SKCM) and lung adenocarcinoma (LUAD) than in normal tissues. The decreased expression of was significantly associated with unfavorable overall survival (OS) in SKCM and LUAD. Additionally, expression was positively correlated with the levels of infiltrating B cells, cluster of differentiation (CD)-8 T cells, and natural killer (NK) cells, suggesting that the infiltration of immune cells could be associated with a good prognosis due to increased expression. Gene ontology (GO) analysis also revealed the relationship between -co-altered genes and the activation of lymphocytes, including B and T cells. Collectively, this study shows that expression is positively correlated with a good prognosis via the induction of immune infiltration, suggesting that has potential prognostic value in SKCM and LUAD.