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孕期化疗：评估阿霉素用于合并乳腺癌的孕期患者的安全性。

Chemotherapy in Pregnancy: Assessing the Safety of Adriamycin Administration in Pregnancy Complicated by Breast Cancer.

作者信息

Nain Priyanshu, Seth Lakshya, Bell Ashley Shawn, Raval Priyanka, Sharma Gyanendra, Bethel Monique, Sharma Garima, Guha Avirup

机构信息

Cardio-Oncology Program, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.

Medical College of Georgia at Augusta University, Augusta, Georgia, USA.

出版信息

JACC Case Rep. 2023 Nov 12;28:102141. doi: 10.1016/j.jaccas.2023.102141. eCollection 2023 Dec 20.

DOI:10.1016/j.jaccas.2023.102141
PMID:38204522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10774876/
Abstract

Pregnancy-associated breast cancer is challenging to treat. Treatment with chemotherapeutic agents such as anthracyclines poses a risk of cardiotoxicity, despite being considered safe after the second trimester of pregnancy. Management requires multidisciplinary comanagement with cardio-obstetrics, cardiology-oncology, maternal-fetal medicine, and oncology.

摘要

妊娠相关乳腺癌的治疗颇具挑战性。尽管蒽环类等化疗药物在妊娠中期后被认为是安全的，但使用这些药物进行治疗仍存在心脏毒性风险。治疗需要心脏妇产科、心脏肿瘤学、母胎医学和肿瘤学等多学科共同管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4835/10774876/18e432a4ba2d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4835/10774876/ad4f48ba513a/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4835/10774876/18e432a4ba2d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4835/10774876/ad4f48ba513a/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4835/10774876/18e432a4ba2d/gr1.jpg

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本文引用的文献

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Guidelines for Cancer Treatment during Pregnancy: Ethics-Related Content Evolution and Implications for Clinicians.孕期癌症治疗指南：伦理相关内容的演变及对临床医生的启示
Cancers (Basel). 2022 Sep 3;14(17):4325. doi: 10.3390/cancers14174325.
2
Outcome of breast cancer patients treated with chemotherapy during pregnancy compared with non-pregnant controls.妊娠期间接受化疗的乳腺癌患者与非妊娠对照患者的结局比较。
Eur J Cancer. 2022 Jul;170:54-63. doi: 10.1016/j.ejca.2022.04.014. Epub 2022 May 17.
3
Call to Action: Maternal Health and Saving Mothers: A Policy Statement From the American Heart Association.
行动呼吁：孕产妇健康与拯救母亲：美国心脏协会的政策声明。
Circulation. 2021 Oct 12;144(15):e251-e269. doi: 10.1161/CIR.0000000000001000. Epub 2021 Sep 8.
4
Pregnancy-associated breast cancer: nationwide Dutch study confirms a discriminatory aggressive histopathologic profile.妊娠相关乳腺癌：荷兰全国性研究证实其具有侵袭性组织病理学特征差异。
Breast Cancer Res Treat. 2021 Apr;186(3):699-704. doi: 10.1007/s10549-021-06130-w. Epub 2021 Feb 26.
5
Pregnancy Outcomes in Women With Heart Disease: The CARPREG II Study.患有心脏病的女性的妊娠结局：CARPREG II 研究。
J Am Coll Cardiol. 2018 May 29;71(21):2419-2430. doi: 10.1016/j.jacc.2018.02.076.
6
The prognosis of women diagnosed with breast cancer before, during and after pregnancy: a meta-analysis.孕期前、孕期及产后被诊断为乳腺癌的女性的预后：一项荟萃分析。
Breast Cancer Res Treat. 2016 Nov;160(2):347-360. doi: 10.1007/s10549-016-3989-3. Epub 2016 Sep 28.
7
Breast Cancer Diagnosed During Pregnancy: Adapting Recent Advances in Breast Cancer Care for Pregnant Patients.妊娠期乳腺癌诊断：为妊娠患者调整乳腺癌治疗的最新进展。
JAMA Oncol. 2015 Nov;1(8):1145-53. doi: 10.1001/jamaoncol.2015.2413.
8
Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.癌症、妊娠与生育：ESMO 诊断、治疗及随访临床实践指南
Ann Oncol. 2013 Oct;24 Suppl 6:vi160-70. doi: 10.1093/annonc/mdt199. Epub 2013 Jun 27.
9
Increased mortality in women with breast cancer detected during pregnancy and different periods postpartum.妊娠期及产后不同时期诊断乳腺癌的女性死亡率增加。
Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1865-72. doi: 10.1158/1055-9965.EPI-11-0515. Epub 2011 Jul 12.