Lekpittaya Nantaporn, Kocharoen Sumet, Angkanavisul Jintavee, Siriudompas Thanison, Montakantikul Preecha, Paiboonvong Taniya
Clinical Pharmacy Section, Pharmacy Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
J Pharm Policy Pract. 2023 Dec 16;17(1):2288603. doi: 10.1080/20523211.2023.2288603. eCollection 2024.
Drug-related problems (DRPs) are important issues that interfere with therapeutic outcomes and can cause adverse events. Pharmacists play a vital role in identifying and resolving DRPs. This study aimed to determine the characteristics, and severity of DPRs, including clinical pharmacists' interventions.
A retrospective study was conducted at Ramathibodi Hospital, a tertiary university hospital in Thailand. We collected data from the drug-related problem system and the electronic medical record. Descriptive statistics were performed with Statistical Package for Social Sciences (SPSS) software version 18.0.
There were 580 patients (20.44%) who had at least one DRP. We classified 1255 DRPs based on Cipolle-Strand-Morley Criteria 2012. The most common DRPs were the need for additional drug therapy (27.09%), followed by dosage too low (26.93%) and dosage too high (22.31%). Anti-infective agents (23.71%) and omeprazole (2.70%) were the most common drug groups and drugs causing DRPs, respectively. The severity of DRPs was mostly categorised to be 'no harm' (95.46%). Almost all of the interventions were completely accepted by physicians (99.12%).
The most common DRPs were the need for additional drug therapy and dosage adjustment of antimicrobial agents. The clinical pharmacists on wards are effective in preventing and resolving DRPs.
药物相关问题（DRPs）是干扰治疗效果并可能导致不良事件的重要问题。药剂师在识别和解决药物相关问题中起着至关重要的作用。本研究旨在确定药物相关问题的特征和严重程度，包括临床药剂师的干预措施。
在泰国的一家三级大学医院拉玛提博迪医院进行了一项回顾性研究。我们从药物相关问题系统和电子病历中收集数据。使用社会科学统计软件包（SPSS）18.0版进行描述性统计。
有580名患者（20.44%）至少存在一个药物相关问题。我们根据2012年西波勒-斯特兰德-莫利标准对1255个药物相关问题进行了分类。最常见的药物相关问题是需要额外的药物治疗（27.09%），其次是剂量过低（26.93%）和剂量过高（22.31%）。抗感染药物（23.71%）和奥美拉唑（2.70%）分别是导致药物相关问题最常见的药物类别和药物。药物相关问题的严重程度大多被归类为“无伤害”（95.46%）。几乎所有的干预措施都被医生完全接受（99.12%）。
最常见的药物相关问题是需要额外的药物治疗和抗菌药物剂量调整。病房临床药剂师在预防和解决药物相关问题方面是有效的。
