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Mind the Gap: Does Junctophilin 2 Gear the Coupled-Clock System in Pacemaker Cardiomyocytes?

作者信息

Glukhov Alexey V, Gorelik Julia

机构信息

Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

出版信息

JACC Basic Transl Sci. 2023 Dec 26;8(12):1589-1591. doi: 10.1016/j.jacbts.2023.09.015. eCollection 2023 Dec.

DOI:10.1016/j.jacbts.2023.09.015
PMID:38205355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10774607/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7634/10774607/23eeca9a896e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7634/10774607/23eeca9a896e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7634/10774607/23eeca9a896e/ga1.jpg

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本文引用的文献

1
Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade.由连接蛋白2表达沉默引起的交界性异位性心动过速对兰尼碱受体阻断具有选择性敏感性。
JACC Basic Transl Sci. 2023 Sep 27;8(12):1577-1588. doi: 10.1016/j.jacbts.2023.07.008. eCollection 2023 Dec.
2
Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity.结蛋白 2 表达减少导致心脏结组织细胞内钙离子驱动自动性增加。
Circ Arrhythm Electrophysiol. 2023 Feb;16(2):e010858. doi: 10.1161/CIRCEP.122.010858. Epub 2023 Jan 27.
3
Cellular and Molecular Mechanisms of Functional Hierarchy of Pacemaker Clusters in the Sinoatrial Node: New Insights into Sick Sinus Syndrome.
窦房结中起搏细胞簇功能层级的细胞和分子机制：病态窦房结综合征的新见解
J Cardiovasc Dev Dis. 2021 Apr 13;8(4):43. doi: 10.3390/jcdd8040043.
4
EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2.EL20，一种有效的抗心律失常化合物，选择性地抑制钙调蛋白缺失的兰尼碱受体 2 型。
Heart Rhythm. 2018 Apr;15(4):578-586. doi: 10.1016/j.hrthm.2017.12.017. Epub 2017 Dec 14.
5
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.急性 junctophilin 敲低后小鼠连接膜复合结构破坏和兰尼碱受体过度激活。
Circulation. 2011 Mar 8;123(9):979-88. doi: 10.1161/CIRCULATIONAHA.110.006437. Epub 2011 Feb 21.