Nakashima Yuki, Fudeyasu Kenichi, Kataoka Yuki, Taito Shunsuke, Ariie Takashi, Mikami Yukio
Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, JPN.
Department of Systematic Reviewers, Scientific Research WorkS Peer Support Group (SRWS-PSG), Osaka, JPN.
Cureus. 2023 Dec 10;15(12):e50287. doi: 10.7759/cureus.50287. eCollection 2023 Dec.
This study aimed to assess the effectiveness of pelvic floor muscle training (PFMT) for fecal incontinence (FI) and health-related quality of life (HR-QOL) after colorectal cancer surgery. This systematic review (SR) and meta-analysis included randomized controlled trials (RCTs) that examined the effects of PFMT after colorectal cancer surgery, which were extracted from several databases in January 2023. The primary outcomes were FI (Wexner scores), HR-QOL, and adverse events. We used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence (CoE). A total of seven RCTs were included. Our SR results suggested that PFMT showed little to no difference in FI (mean difference 0.62 higher; 95% CI: -1.26 to 2.5, low CoE) and adverse events (risk ratio 5.78; 95% CI: 0.28-117.22, low CoE). Two adverse events occurred in the PFMT group (anastomotic stenosis, suboptimal use of laxatives) and were not observed in controls. HR-QOL was measured in two RCTs using 12-item Short Form Survey (SF-12) and fecal incontinence quality of life (FIQL). Two RCTs found no trend toward a positive impact on HR-QOL. Higher quality RCTs on colorectal cancer after surgery are required. Furthermore, extending the duration of the PFMT intervention may be necessary to ensure its success.
本研究旨在评估盆底肌肉训练(PFMT)对结直肠癌手术后大便失禁(FI)及健康相关生活质量(HR-QOL)的有效性。本系统评价(SR)和荟萃分析纳入了2023年1月从多个数据库中提取的、研究结直肠癌手术后PFMT效果的随机对照试验(RCT)。主要结局指标为FI(韦克斯纳评分)、HR-QOL和不良事件。我们采用推荐分级、评估、制定与评价(GRADE)方法评估证据确定性(CoE)。共纳入7项RCT。我们的SR结果表明,PFMT在FI(平均差值高0.62;95%CI:-1.26至2.5,CoE低)和不良事件(风险比5.78;95%CI:0.28 - 117.22,CoE低)方面几乎没有差异。PFMT组发生了2例不良事件(吻合口狭窄、泻药使用不当),而对照组未观察到。两项RCT使用12项简明健康调查问卷(SF - 12)和大便失禁生活质量量表(FIQL)对HR-QOL进行了测量。两项RCT均未发现对HR-QOL有积极影响的趋势。需要开展更高质量的结直肠癌术后RCT。此外,可能有必要延长PFMT干预的持续时间以确保其成功。