[1-C]丙酮酸在 DO 中用于脑的极化 MRI 的首次人体评估：一项安全性和可行性研究。
First in-human evaluation of [1-C]pyruvate in DO for hyperpolarized MRI of the brain: A safety and feasibility study.
机构信息
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Radiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA.
出版信息
Magn Reson Med. 2024 Jun;91(6):2559-2567. doi: 10.1002/mrm.30002. Epub 2024 Jan 11.
PURPOSE
To investigate the safety and value of hyperpolarized (HP) MRI of [1-C]pyruvate in healthy volunteers using deuterium oxide (DO) as a solvent.
METHODS
Healthy volunteers (n = 5), were injected with HP [1-C]pyruvate dissolved in DO and imaged with a metabolite-specific 3D dual-echo dynamic EPI sequence at 3T at one site (Site 1). Volunteers were monitored following the procedure to assess safety. Image characteristics, including SNR, were compared to data acquired in a separate cohort using water as a solvent (n = 5) at another site (Site 2). The apparent spin-lattice relaxation time (T) of [1-C]pyruvate was determined both in vitro and in vivo from a mono-exponential fit to the image intensity at each time point of our dynamic data.
RESULTS
All volunteers completed the study safely and reported no adverse effects. The use of DO increased the T of [1-C]pyruvate from 66.5 ± 1.6 s to 92.1 ± 5.1 s in vitro, which resulted in an increase in signal by a factor of 1.46 ± 0.03 at the time of injection (90 s after dissolution). The use of DO also increased the apparent relaxation time of [1-C]pyruvate by a factor of 1.4 ± 0.2 in vivo. After adjusting for inter-site SNR differences, the use of DO was shown to increase image SNR by a factor of 2.6 ± 0.2 in humans.
CONCLUSIONS
HP [1-C]pyruvate in DO is safe for human imaging and provides an increase in T and SNR that may improve image quality.
目的
使用重水 (DO) 作为溶剂，研究健康志愿者中 [1-C]丙酮酸的超极化 (HP) MRI 的安全性和价值。
方法
向 5 名健康志愿者（n=5）注射溶解在 DO 中的 HP [1-C]丙酮酸，并在 3T 下使用代谢物特异性 3D 双回波动态 EPI 序列在一个部位（部位 1）进行成像。在程序后监测志愿者以评估安全性。图像特征，包括 SNR，与在另一个部位（部位 2）使用水作为溶剂（n=5）获得的数据进行比较。通过对每个时间点的图像强度进行单指数拟合，从体外和体内确定 [1-C]丙酮酸的表观自旋-晶格弛豫时间 (T)。
结果
所有志愿者均安全完成研究，无不良反应报告。DO 的使用将 [1-C]丙酮酸的 T 从 66.5±1.6 s 增加到体外的 92.1±5.1 s，这导致在注射时（溶解后 90 s）信号增加了 1.46±0.03 倍。DO 的使用还使 [1-C]丙酮酸的表观弛豫时间在体内增加了 1.4±0.2 倍。在调整了站点间 SNR 差异后，证明 DO 的使用可使人类图像的 SNR 增加 2.6±0.2 倍。
结论
DO 中的 HP [1-C]丙酮酸对人体成像安全，并提供 T 和 SNR 的增加，这可能会提高图像质量。
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