Tang Yi, Zhang Rulei, Dong Yujie, Yu Songcheng, Wu Yongjun, Xiao Yumei, Guo Hongchao
Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China.
College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Chem Commun (Camb). 2024 Feb 1;60(11):1436-1439. doi: 10.1039/d3cc06012h.
In this paper, benzo-fused cyclic carbonates were designed and synthesized as a new type of precursor of π-allylpalladium zwitterionic intermediates, and were applied in Pd-catalyzed diastereo- and enantioselective (4+3) cycloaddition with ,-cyclic azomethine imines, leading to various biologically important 1,3,4-benzoxadiazepine derivatives in 43-99% yields with 6 : 1 to >20 : 1 dr and up to 95% ee.
在本文中，苯并稠合环状碳酸酯被设计并合成为一种新型的π-烯丙基钯两性离子中间体前体，并应用于钯催化的与α,β-环状甲亚胺亚胺的非对映和对映选择性(4+3)环加成反应，以43-99%的产率、6:1至>20:1的非对映选择性和高达95%的对映体过量得到了各种具有重要生物学意义的1,3,4-苯并二氮杂䓬衍生物。
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