Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China.
College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Chem Commun (Camb). 2022 Jun 8;58(46):6646-6649. doi: 10.1039/d2cc01134d.
In this paper, a new type of δ-vinylvalerolactone was designed and synthesized, and used as a new precursor in Pd-catalyzed [6+3] cycloaddition with azomethine imines, leading to nine-membered 1,2-dinitrogen-containing heterocycles in 77-98% yields with >20 : 1 d.r. These nine-membered ring-fused products were further transformed into unusual tetracyclic bridged-ring compounds without loss of the diastereoselectivities.
在本文中，设计并合成了一种新型的δ-乙烯基缬草内酯，并将其用作 Pd 催化的吖嗪亚胺[6+3]环加成反应的新前体，以 77-98%的收率和>20 : 1 的 d.r. 得到了九个成员的 1,2-二氮杂环化合物。这些九元环稠合产物进一步转化为非典型的四环桥环化合物，而立体选择性不受影响。
