From the Department of Internal Medicine, Burnett School of Medicine at Texas Christian University, Fort Worth, Texas (MS); Consultants in Cardiovascular Medicine and Science-Fort Worth, Fort Worth, Texas (MS); Department of Pharmacy Practice, Thomas J Long School of Pharmacy, University of the Pacific, Stockton, California (RJS, SAS); Department of Physical Medicine and Rehabilitation, UT Southwestern Medical Center, Dallas, Texas (JC, ML); Flow Therapy, Fort Worth, Texas (JF, SAS); and Department of Physical Medicine and Rehabilitation, Joe R. and Teresa Lozano Long School of Medicine, San Antonio, Texas (MV-G).
Am J Phys Med Rehabil. 2024 Aug 1;103(8):734-739. doi: 10.1097/PHM.0000000000002433. Epub 2024 Jan 3.
OBJECTIVE: The aim of this study is to determine the effects of enhanced external counterpulsation (EECP) in patients with long COVID and objectively assessed cognitive impairment. DESIGN: A retrospective evaluation of long COVID patients referred for EECP, with cognitive sequela, and having completed an objective digital assessment before and after therapy. Patients had either cognitive impairment or no cognitive impairment at baseline. We assessed changes in composite score using multifactor analysis of variance. Multiple linear and logistic regression analyses were conducted to evaluate several independent variables. RESULTS: Eighty long COVID patients (38 cognitive impairment vs. 42 no cognitive impairment) were included for analyses. All baseline characteristics were well matched. There was significant improvement in composite score post EECP in those with objective cognitive impairment at baseline. There were no notable documented safety concerns. CONCLUSIONS: This is the first study showing that EECP led to significant improvement in cognitive functioning of long COVID patients with objectively defined cognitive impairment. Although a lack of a negative control group is a limitation of this study, EECP seems to be highly safe and effective with the potential for widespread application.
目的：本研究旨在确定增强型体外反搏（EECP）对长新冠患者和客观评估认知障碍的影响。
设计：对接受 EECP 治疗、有认知后遗症且在治疗前后完成客观数字评估的长新冠患者进行回顾性评估。患者在基线时有认知障碍或无认知障碍。我们使用多因素方差分析评估复合评分的变化。进行了多元线性和逻辑回归分析，以评估多个独立变量。
结果：共纳入 80 例长新冠患者（38 例认知障碍与 42 例无认知障碍）进行分析。所有基线特征均匹配良好。基线时存在客观认知障碍的患者，EECP 后复合评分有显著改善。没有明显的记录到的安全性问题。
结论：这是第一项表明 EECP 可显著改善有客观定义的认知障碍的长新冠患者认知功能的研究。尽管缺乏阴性对照组是本研究的一个局限性，但 EECP 似乎非常安全有效，具有广泛应用的潜力。
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