Harbin Medical University Affiliated Sixth Hospital, Harbin, China.
The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Medicine (Baltimore). 2023 Dec 29;102(52):e36597. doi: 10.1097/MD.0000000000036597.
The murine sarcoma virus oncogene (KRAS) is a key gene associated with tumorigenesis and chemotherapy resistance. However, little is known about the molecular mechanisms and immune infiltration of RASs in lung adenocarcinoma. Gene Expression Profiling Interaction Analysis was used for RASs expression analysis, and Kaplan-Meier analysis was used to analyze the potential of RASs in clinical prognosis. The effect of KRAS on immune infiltration was analyzed by TIMER. In addition, the correlation between KRAS expression and molecular mechanisms was investigated by TIMER and Cancer Single-cell State Atlas (Cancer SEA). KRAS expression levels were associated with good prognosis and tumor progression. Furthermore, KRAS expression correlates with several immune cell markers and regulates tumorigenesis. KRAS expression is involved in the regulation of multiple oncogenes and tumorigenesis, especially in the prognosis and immune infiltration of lung adenocarcinoma.
鼠肉瘤病毒癌基因（KRAS）是与肿瘤发生和化疗耐药相关的关键基因。然而，关于肺腺癌中 RAS 的分子机制和免疫浸润知之甚少。我们使用基因表达谱互作分析进行 RAS 表达分析，并使用 Kaplan-Meier 分析分析 RAS 在临床预后中的潜力。TIMER 用于分析 KRAS 对免疫浸润的影响。此外，通过 TIMER 和癌症单细胞状态图谱（Cancer SEA）研究 KRAS 表达与分子机制之间的相关性。KRAS 表达水平与良好的预后和肿瘤进展相关。此外，KRAS 表达与几种免疫细胞标志物相关，并调节肿瘤发生。KRAS 表达参与多个癌基因的调控和肿瘤发生，特别是在肺腺癌的预后和免疫浸润中。
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