Griffin C L, Musselman R P, Yeates D B, Raju T N, Harshbarger R D, Lourenco R V
Lab Anim Sci. 1986 Dec;36(6):686-90.
To conduct laboratory studies in unsedated animals that were similar anatomically and physiologically to man, five full term baboons (four Papio cynocephalus anubis, one Papio cynocephalus cynocephalus) were hand-reared. These infants were used as unsedated animal models in short-term lung clearance studies conducted from birth to 2 years of age. The hand-rearing techniques described here encouraged the formation of an infant-human rearer bond that permitted us to control the level of expressed aggressive behavior as the infant matured. These techniques resulted in baboons which displayed subordinate behavior, showed positive reception to human contact (without evidence of negative stereotypic behavioral anomalies) and remained cooperative subjects for our investigations of short-term pulmonary clearance. The baboons generally were above average in weight in comparison to conspecifically-reared baboons of similar age, sex and species. Representative lung retention curves presented on one baboon demonstrate the feasibility of lung clearance studies in these hand-reared animals. Due to its suitability for unsedated studies, this baboon model may be considered for other types of laboratory investigations.
为了在解剖学和生理学上与人类相似的未麻醉动物身上进行实验室研究，我们人工饲养了5只足月的狒狒（4只东非狒狒，1只黄狒狒）。这些幼崽在从出生到2岁的短期肺清除研究中被用作未麻醉的动物模型。这里描述的人工饲养技术促进了幼崽与人类饲养者之间的亲密关系的形成，这使我们能够在幼崽成长过程中控制其表现出的攻击性行为水平。这些技术培育出的狒狒表现出顺从行为，对人类接触表现出积极反应（没有负面刻板行为异常的迹象），并且在我们对短期肺清除的研究中仍然是合作良好的实验对象。与同龄、同性和同物种的自然饲养的狒狒相比，这些狒狒的体重通常高于平均水平。在一只狒狒身上呈现的代表性肺滞留曲线证明了在这些人工饲养的动物身上进行肺清除研究的可行性。由于其适用于未麻醉研究，这种狒狒模型可考虑用于其他类型的实验室研究。
