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高效液相色谱法测定职业接触杀虫脒工人尿液中的代谢物4-氯邻甲苯胺。

HPLC determination of the metabolite 4-chloro-o-toluidine in the urine of workers occupationally exposed to chlordimeform.

作者信息

Geyer R, Fattal F

出版信息

J Anal Toxicol. 1987 Jan-Feb;11(1):24-6. doi: 10.1093/jat/11.1.24.

DOI:10.1093/jat/11.1.24
PMID:3821074
Abstract

A reversed phase HPLC method (UV detection) is described or the analysis of 4-chloro-o-toluidine in the urine of workers occupationally exposed to chlordimeform. The procedure involves extracting an alkaline hydrolysate of urine with hexane, evaporating off the solvent, and reconstituting the residue with an aqueous acetonitrile mobile phase.

摘要

描述了一种反相高效液相色谱法（紫外检测），用于分析职业接触杀虫脒的工人尿液中的4-氯邻甲苯胺。该程序包括用己烷萃取尿液的碱性水解产物，蒸发掉溶剂，并用乙腈水溶液流动相复溶残渣。

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1
HPLC determination of the metabolite 4-chloro-o-toluidine in the urine of workers occupationally exposed to chlordimeform.高效液相色谱法测定职业接触杀虫脒工人尿液中的代谢物4-氯邻甲苯胺。
J Anal Toxicol. 1987 Jan-Feb;11(1):24-6. doi: 10.1093/jat/11.1.24.
2
Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine.杀虫剂杀虫脒、其代谢物4-氯邻甲苯胺以及结构相关化学品邻甲苯胺对异生物质生物转化的诱导作用。
Biochem Pharmacol. 1988 Jul 1;37(13):2529-35. doi: 10.1016/0006-2952(88)90242-0.
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Simultaneous determination of amitraz, chlordimeform, formetanate and their main metabolites in human urine by high performance liquid chromatography-tandem mass spectrometry.高效液相色谱-串联质谱法同时测定人尿液中的双甲脒、杀虫脒、速灭威及其主要代谢物
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Gas-liquid chromatographic determination of chlordimeform and its metabolites in cargo rice and husk.气液色谱法测定大米及稻壳中杀虫脒及其代谢物的含量
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The metabolic fate of chlordimeform [N-(4-chloro-o-toly)-N', N'-dimethylformamidine] in human embryonic lung cell cultures.杀虫脒[N-(4-氯邻甲苯基)-N′,N′-二甲基甲脒]在人胚肺细胞培养中的代谢归宿
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Toxicity, penetration, and metabolism of chlordimeform and its N-demethyl metabolite in cabbage looper larvae.杀虫脒及其N-去甲基代谢物在粉纹夜蛾幼虫体内的毒性、渗透及代谢
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Biological monitoring for occupational exposures to o-toluidine and aniline.职业接触邻甲苯胺和苯胺的生物监测
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Incidence of bladder cancer in a cohort of workers exposed to 4-chloro-o-toluidine while synthesising chlordimeform.在一群合成杀虫脒时接触4-氯邻甲苯胺的工人中膀胱癌的发病率。
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The mammalian spot test and its use for testing of mutagenic and carcinogenic potential: experience with the pesticide chlordimeform, its principal metabolites and the drug lisuride hydrogen maleate.
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Metabolic fate of chlordimeform in soil under aerobic, anaerobic, and sterile conditions.在需氧、厌氧和无菌条件下，土壤中杀虫脒的代谢命运。
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