Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW, Australia; Newcastle University Faculty of Health, Callaghan Campus, Newcastle, NSW, Australia.
School of Mechanical Engineering, University of New South Wales, Sydney, NSW, Australia.
Neuroimage. 2024 Feb 1;286:120517. doi: 10.1016/j.neuroimage.2024.120517. Epub 2024 Jan 10.
Recently, Clarke et al. published a study using spinal cord susceptibility weighted imaging in multiple sclerosis patients at 7T. They discovered dilated intradural extramedullary veins surrounding the cord. The purpose of this commentary is to point out some recent research by our group, which suggests this dilatation also occurs in the bridging cortical veins surrounding the brain. The dilatation indicates a focal elevation in the venous pressure secondary to impedance mismatching. Due to the shared outflow geometry, dilatation of the outflow veins will obstruct the glymphatic pathway of the spinal cord altering the immune response.
最近，Clarke 等人发表了一项在 7T 下对多发性硬化症患者使用脊髓磁化率加权成像的研究。他们发现脊髓周围的硬膜内髓外静脉扩张。本评论的目的是指出我们小组的一些最新研究，这些研究表明这种扩张也发生在大脑周围的桥接皮质静脉中。扩张表明静脉压力的局灶性升高是由于阻抗不匹配引起的。由于共享的流出几何形状，流出静脉的扩张将阻塞脊髓的神经淋巴通路，改变免疫反应。
