Watanabe Naoki, Watari Tomohisa, Otsuka Yoshihito, Hosokawa Naoto, Yamagata Kazufumi, Fujioka Miyuki
Department of Clinical Laboratory, Kameda Medical Center, Higashi-cho 929, Kamogawa, Chiba, Japan; Graduate School of Health Sciences, Hirosaki University, Hon-cho 66-1, Hirosaki, Aomori, Japan.
Department of Clinical Laboratory, Kameda Medical Center, Higashi-cho 929, Kamogawa, Chiba, Japan.
Anaerobe. 2024 Feb;85:102818. doi: 10.1016/j.anaerobe.2024.102818. Epub 2024 Jan 10.
Ruminococcus gnavus is a rare human pathogen, and clinical data on R. gnavus infection are insufficient. This retrospective study aimed to investigate the clinical characteristics of R. gnavus infections.
This study included 13 cases of bacteremia and three cases of non-bacteremia infections caused by R. gnavus. We evaluated the patient data, infection source, clinical outcomes, and antimicrobial susceptibility of R. gnavus isolates for these cases.
The median age of patients was 75 years (range 47-95), and eight patients were female. Twelve cases were presumed to have an intra-abdominal infection source, and the remaining four cases had an unknown infection source. The most common underlying conditions were immunosuppression (seven cases), solid tumors (seven cases), and history of gastrointestinal surgery (five cases). Thirteen patients exhibited gastrointestinal problems (dysfunction, bleeding, intra-abdominal infection, or inflammation). Multiple pathogens were observed in six cases, and fatal outcomes were recorded in three cases. Antimicrobial susceptibility data were available for eight isolates, all of which exhibited low minimum inhibitory concentrations to penicillin (≤0.03 μg/mL), ampicillin-sulbactam (≤0.5 μg/mL), piperacillin-tazobactam (≤4 μg/mL), and metronidazole (≤0.5-1 μg/mL).
Ruminococcus gnavus is frequently associated with an intra-abdominal infection source, and treatment strategies should consider the possibility of multiple pathogens.
纤细瘤胃球菌是一种罕见的人类病原体，关于纤细瘤胃球菌感染的临床数据不足。本回顾性研究旨在调查纤细瘤胃球菌感染的临床特征。
本研究纳入了13例由纤细瘤胃球菌引起的菌血症病例和3例非菌血症感染病例。我们评估了这些病例的患者数据、感染源、临床结局以及纤细瘤胃球菌分离株的抗菌药敏情况。
患者的中位年龄为75岁（范围47 - 95岁），8例为女性。12例推测有腹腔内感染源，其余4例感染源不明。最常见的基础疾病是免疫抑制（7例）、实体瘤（7例）和胃肠道手术史（5例）。13例患者出现胃肠道问题（功能障碍、出血、腹腔内感染或炎症）。6例观察到多种病原体，3例记录有致命结局。有8株分离株的抗菌药敏数据，所有分离株对青霉素（≤0.03μg/mL）、氨苄西林 - 舒巴坦（≤0.5μg/mL）、哌拉西林 - 他唑巴坦（≤4μg/mL）和甲硝唑（≤0.5 - 1μg/mL）的最低抑菌浓度均较低。
纤细瘤胃球菌常与腹腔内感染源相关，治疗策略应考虑多种病原体的可能性。
