Isaacs J H, Thompson W B, Cassisi N J, Million R R
Laryngoscope. 1987 Mar;97(3 Pt 1):267-70.
Complication rates are lower using postoperative radiation therapy and cure rates at least compatible to preoperative radiation therapy. However, one of the concerns with postoperative radiation treatment is the possibility of delay in beginning the treatment because of an unhealed surgical wound. A delay of more than 6 weeks is detrimental. In order to study the effect of radiation therapy on incompletely healed wounds, a retrospective chart review of such cases during the period 1977 to 1984 was undertaken. One hundred and eighty-five patients had planned postoperative radiation therapy, and 13 of these began radiation therapy with an unhealed wound or fistula. Six of 10 wounds closed spontaneously, 4 required surgical closure, and 3 failed to heal. Seven patients in this study died with cancer, 2 died of other causes, 3 are alive without disease, and 1 patient remains alive with disease. We conclude that giving radiation therapy to an open wound with appropriate precaution can be done without serious complications.
使用术后放射治疗的并发症发生率较低,治愈率至少与术前放射治疗相当。然而,术后放射治疗的一个问题是,由于手术伤口未愈合,可能会延迟开始治疗。延迟超过6周是有害的。为了研究放射治疗对未完全愈合伤口的影响,我们对1977年至1984年期间此类病例进行了回顾性图表审查。185例患者计划接受术后放射治疗,其中13例在伤口或瘘管未愈合的情况下开始放射治疗。10个伤口中有6个自行愈合,4个需要手术缝合,3个未愈合。本研究中有7例患者死于癌症,2例死于其他原因,3例无病存活,1例带癌存活。我们得出结论,在采取适当预防措施的情况下,对开放性伤口进行放射治疗不会引发严重并发症。