Salma Nunciada, Wang-Evers Michael, Karasik Daniel, Yerevanian Armen, Downs Heather, Luo Tuanlian, Doyle Abigail E, Tannous Zeina, Cacicedo Jose M, Manstein Dieter
Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA.
Technion - Israel Institute of Technology, Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel.
iScience. 2023 Dec 7;27(1):108677. doi: 10.1016/j.isci.2023.108677. eCollection 2024 Jan 19.
Fractional laser (FL) treatment is a common dermatologic procedure that generates arrays of microscopic treatment zones separated by intact tissue, promoting fast wound healing. Using a mouse model, we introduced a large area fractional laser treatment (LAFLT) method to study metabolic effects. Using two laser modalities, ablative FL (AFL) and non-ablative FL (NAFL), and exposing different percentages of mice's total body surface area (TBSA), we followed changes in metabolic parameters in real time using metabolic cages. Additionally, body composition, markers of inflammation, neurohormonal signaling, and browning of adipocytes were investigated. LAFLT, especially in high TBSA groups, had specific metabolic effects such as significantly increased average daily energy expenditure, increased fat mass loss, systemic browning of adipocytes, and inflammatory states, without compromising other organs. The ability of LAFLT to stimulate metabolism in a controlled way could develop into a promising therapeutic treatment to induce positive metabolic changes that replace or augment systemic drugs.
分次激光（FL）治疗是一种常见的皮肤科手术，它会产生由完整组织分隔的微小治疗区域阵列，促进伤口快速愈合。我们使用小鼠模型，引入了大面积分次激光治疗（LAFLT）方法来研究代谢效应。我们使用两种激光模式，即剥脱性分次激光（AFL）和非剥脱性分次激光（NAFL），并暴露小鼠不同百分比的体表面积（TBSA），使用代谢笼实时跟踪代谢参数的变化。此外，还研究了身体成分、炎症标志物、神经激素信号传导以及脂肪细胞的褐变。LAFLT，尤其是在高TBSA组中，具有特定的代谢效应，如平均每日能量消耗显著增加、脂肪量减少、脂肪细胞全身性褐变以及炎症状态，而不会损害其他器官。LAFLT以可控方式刺激新陈代谢的能力可能发展成为一种有前景的治疗方法，以诱导积极的代谢变化，替代或增强全身性药物。
