Mbiine Ronald, Wayengera Misaki, Kiwanuka Noah, Munabi Ian, Muwonge Haruna, Nakanwagi Cephas, Joloba Moses, Galukande Moses
Department of Surgery, College of Health Sciences, Makerere University Kampala, Uganda.
Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University Kampala, Uganda.
Am J Stem Cells. 2023 Dec 15;12(5):98-111. eCollection 2023.
Keloids and hypertrophic scars are some of the most common skin conditions globally, associated with poor treatment response and high recurrence rates. Autologous adipose-derived stromal vascular fraction (SVF) is increasingly recognized as an emerging therapy albeit limited literature on its outcome in scar treatment. This review aimed to describe the current practices and outcomes of adipose-derived stromal Vascular Fraction in scar treatment.
This systematic review assessed articles describing the use of SVF in scar treatment published between 2000 and 2023. Article searches of Medline/PubMed, Cochrane Library, and Embase databases using Mesh terms and the Boolean operators ("AND", "OR") by two independent researchers were done whilst following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Clinical studies assessing SVF in scar treatment with a primary outcome measure being an improvement in scar characteristics including the thickness, scar assessment scores were included.
Among the 1425 studies identified in the search, 20 studies met the inclusion criteria with a total of 493 patients included. Eight of these were clinical trials with the rest being observational studies. Follow-up ranged from 3 months to 24 months. In all studies, there was an improvement in scar characteristics following single-dose treatment with SVF or its equivalent. All studies reported SVF to be safe.
The review found that autologous adipose-derived SVF is a clinically effective therapy for keloids and scar treatment.
瘢痕疙瘩和增生性瘢痕是全球最常见的皮肤疾病，治疗反应不佳且复发率高。自体脂肪来源的基质血管成分（SVF）越来越被认为是一种新兴疗法，尽管关于其在瘢痕治疗中效果的文献有限。本综述旨在描述脂肪来源的基质血管成分在瘢痕治疗中的当前实践和结果。
本系统综述评估了2000年至2023年间发表的描述SVF在瘢痕治疗中应用的文章。两名独立研究人员按照系统评价和Meta分析的首选报告项目（PRISMA）指南，使用医学主题词和布尔运算符（“AND”、“OR”）在Medline/PubMed、Cochrane图书馆和Embase数据库中进行文章检索。纳入以瘢痕特征改善（包括厚度、瘢痕评估评分）为主要结局指标评估SVF在瘢痕治疗中的临床研究。
在检索到的1425项研究中，20项研究符合纳入标准，共纳入493例患者。其中8项为临床试验，其余为观察性研究。随访时间为3个月至24个月。在所有研究中，单次使用SVF或其等效物治疗后瘢痕特征均有改善。所有研究均报告SVF是安全的。
该综述发现，自体脂肪来源的SVF是治疗瘢痕疙瘩和瘢痕的一种临床有效疗法。
