Rokhsartalab Azar Pourya, Karimi Sarmad, Haghtalab Arian, Taram Saman, Hejazi Milad, Sadeghpour Sonia, Pashaei Mohammad Reza, Ghasemnejad-Berenji Hojat, Taheri-Anganeh Mortaza
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran; Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
J Reprod Immunol. 2024 Mar;162:104192. doi: 10.1016/j.jri.2024.104192. Epub 2024 Jan 6.
There is a suggested pathophysiology associated with endometrial microbiota in cases where repeated implantation failure of high-quality embryos is observed. However, there is a suspected association between endometrial microbiota and the pathogenesis of implantation failure. However, there is still a lack of agreement on the fundamental composition of the physiological microbiome within the uterine cavity. This is primarily due to various limitations in the studies conducted, including small sample sizes and variations in experimental designs. As a result, the impact of bacterial communities in the endometrium on human reproduction is still a subject of debate. In this discourse, we undertake a comprehensive examination of the existing body of research pertaining to the uterine microbiota and its intricate interplay with the process of embryo implantation.
在观察到高质量胚胎反复着床失败的病例中，存在一种与子宫内膜微生物群相关的病理生理学假说。然而，子宫内膜微生物群与着床失败的发病机制之间存在疑似关联。然而，对于子宫腔内生理微生物群的基本组成仍缺乏共识。这主要是由于所进行研究的各种局限性，包括样本量小和实验设计的差异。因此，子宫内膜中细菌群落对人类生殖的影响仍是一个有争议的话题。在本文中，我们对现有的关于子宫微生物群及其与胚胎着床过程复杂相互作用的研究进行了全面审视。
