Division of Reproductive Endocrinology and Infertility.
Inbiome, Amsterdam, The Netherlands.
Curr Opin Obstet Gynecol. 2022 Jun 1;34(3):122-132. doi: 10.1097/GCO.0000000000000782.
Review the latest research on the female urogenital microbiome as a predictor of successful implantation.
Lactobacillus crispatus seems to be beneficial species in a healthy female genital tract, although the presence of anaerobic bacteria and their impact has yet to be determined. The vaginal microbiome is associated with assisted reproductive technology (ART) outcome in terms of successful implantation and pregnancy. Approaches restoring a dysbiotic vaginal microbiome seem promising. It is questionable if a unique endometrial microbiome exists, given the low bacterial biomass, the invasiveness of endometrial sampling, and its associated high contamination risk. Future studies should focus on the whole microbiome using proteomics and metabolomics, as well as the virome to get a more holistic understanding of its role in reproduction.
The vaginal and endometrial compartments are being studied to determine a healthy and unhealthy microbiome composition. Defining a healthy composition could provide insight into physiological processes related to the success of embryo implantation. The vaginal microbiome is easily accessible and its composition can be reliably assessed and can be associated with ART outcome. The existence of an endometrial or uterine microbiome is still debated, due to the combination of low biomass and unavoidable high risk of contamination during sampling.
综述女性泌尿生殖微生物组作为成功着床预测因子的最新研究进展。
尽管尚未确定厌氧菌的存在及其影响，但脆拟杆菌似乎是健康女性生殖道有益的物种。阴道微生物组与辅助生殖技术（ART）的成功着床和妊娠结局相关。恢复阴道微生物组生态失调的方法似乎很有前景。鉴于子宫内膜采样的侵袭性及其相关的高污染风险，低细菌生物量，是否存在独特的子宫内膜微生物组仍存在疑问。未来的研究应使用蛋白质组学和代谢组学以及病毒组学来关注整个微生物组，以更全面地了解其在生殖中的作用。
目前正在研究阴道和子宫内膜腔，以确定健康和不健康的微生物组组成。定义健康的组成可能有助于深入了解与胚胎着床成功相关的生理过程。阴道微生物组易于获取，其组成可以可靠评估，并与 ART 结果相关。由于采样过程中生物量低且不可避免的高污染风险，子宫内膜或子宫微生物组的存在仍存在争议。
