Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.
J Perinatol. 2024 Feb;44(2):307-313. doi: 10.1038/s41372-024-01867-w. Epub 2024 Jan 13.
To estimate the association of transpyloric feeding (TPF) with the composite outcome of tracheostomy or death for patients with severe bronchopulmonary dysplasia (sBPD).
Retrospective multi-center cohort study of preterm infants <32 weeks with sBPD receiving enteral feedings. We compared infants who received TPF at 36, 44, or 50 weeks post-menstrual age to those who did not receive TPF at any of those timepoints. Odds ratios were adjusted for gestational age, small for gestational age, male sex, and invasive ventilation and FiO at 36 weeks.
Among 1039 patients, 129 (12%) received TPF. TPF was associated with an increased odds of tracheostomy or death (aOR 3.5, 95% CI 2.0-6.1) and prolonged length of stay or death (aOR 3.1, 95% CI 1.9-5.2).
Use of TPF in sBPD after 36 weeks was infrequent and associated with worse in-hospital outcomes, even after adjusting for respiratory severity at 36 weeks.
评估经幽门喂养（TPF）与严重支气管肺发育不良（sBPD）患者气管切开或死亡复合结局的相关性。
对接受肠内喂养的 <32 周龄患有 sBPD 的早产儿进行回顾性多中心队列研究。我们将在胎龄 36、44 或 50 周时接受 TPF 的婴儿与任何时间点均未接受 TPF 的婴儿进行比较。在调整胎龄、小于胎龄、男性、36 周时的有创通气和 FiO2 后，计算比值比。
在 1039 名患者中，有 129 名（12%）接受了 TPF。TPF 与气管切开或死亡的几率增加相关（aOR 3.5，95%CI 2.0-6.1），并与住院时间延长或死亡相关（aOR 3.1，95%CI 1.9-5.2）。
在 36 周后使用 TPF 治疗 sBPD 并不常见，即使在调整 36 周时的呼吸严重程度后，也与更差的院内结局相关。
