Li Song, Chen Mingfei, Wang Zhongyuan, Abudourexiti Waresi, Zhang Liang, Ding Chao, Ding Lin, Gong Jianfeng
Department of General Surgery, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China.
Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Jiangsu, China.
Microbiol Res. 2024 Apr;281:127599. doi: 10.1016/j.micres.2023.127599. Epub 2024 Jan 4.
The colonic mucus layer plays a critical role in maintaining the integrity of the colonic mucosal barrier, serving as the primary defense against colonic microorganisms. Predominantly composed of mucin 2 (MUC2), a glycosylation-rich protein, the mucus layer forms a gel-like coating that covers the colonic epithelium surface. This layer provides a habitat for intestinal microorganisms, which can utilize mucin glycans present in the mucus layer as a sustainable source of nutrients. Additionally, metabolites produced by the microbiota during the metabolism of mucus glycans have a profound impact on host health. Under normal conditions, the production and consumption of mucus maintain a dynamic balance. However, several studies have demonstrated that certain factors, such as dietary fiber deficiency, can enhance the metabolism of mucus glycans by gut bacteria, thereby disturbing this balance and weakening the mucus barrier function of the mucus layer. To better understand the occurrence and development of colon-related diseases, it is crucial to investigate the complex metabolic patterns of mucus glycosylation by intestinal microorganisms. Our objective was to comprehensively review these patterns in order to clarify the effects of mucus layer glycan metabolism by intestinal microorganisms on the host.
结肠黏液层在维持结肠黏膜屏障的完整性方面起着关键作用，是抵御结肠微生物的主要防线。黏液层主要由富含糖基化的蛋白质黏蛋白2（MUC2）组成，形成覆盖结肠上皮表面的凝胶状涂层。这一层为肠道微生物提供了栖息地，肠道微生物可以利用黏液层中存在的黏蛋白聚糖作为可持续的营养来源。此外，微生物群在黏液聚糖代谢过程中产生的代谢产物对宿主健康有深远影响。在正常情况下，黏液的产生和消耗保持动态平衡。然而，多项研究表明，某些因素，如膳食纤维缺乏，可增强肠道细菌对黏液聚糖的代谢，从而扰乱这种平衡并削弱黏液层的黏液屏障功能。为了更好地了解结肠相关疾病的发生和发展，研究肠道微生物对黏液糖基化的复杂代谢模式至关重要。我们的目标是全面综述这些模式，以阐明肠道微生物对黏液层聚糖代谢对宿主的影响。
