肠道黏液及其聚糖：微生物群落的繁荣栖息地。
Intestinal mucus and their glycans: A habitat for thriving microbiota.
机构信息
Department of Medical Biochemistry and Cell Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.
Department of Medical Biochemistry and Cell Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.
出版信息
Cell Host Microbe. 2023 Jul 12;31(7):1087-1100. doi: 10.1016/j.chom.2023.05.026.
Abstract
The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. In the intestine, goblet cells are specialized in controlling glycosylation and making mucus. Some microbiota members are known to encode multiple proteins that are predicted to bind and/or cleave mucin glycans. The interactions between commensal microbiota and host mucins drive intestinal colonization, while at the same time, the microbiota can utilize the glycans on mucins and affect the colonic mucus properties. This review will examine this interaction between commensal microbes and intestinal mucins and discuss how this interplay affects health and disease.
摘要
结肠黏液层组织有序，内层黏液层可防止细菌穿透，外层黏液层扩张以允许微生物群定植。黏液的主要成分是 MUC2，这是一种糖蛋白，经过广泛修饰，尤其是 O-聚糖。在肠道中，杯状细胞专门控制糖基化并产生黏液。已知一些微生物群成员编码多种预测可结合和/或裂解黏蛋白聚糖的蛋白质。共生微生物群与宿主黏蛋白之间的相互作用驱动肠道定植，同时，微生物群可以利用黏蛋白上的聚糖并影响结肠黏液特性。本综述将检查共生微生物与肠道黏蛋白之间的这种相互作用，并讨论这种相互作用如何影响健康和疾病。
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