Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, USA.
Division of Plastic and Reconstructive Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA; Research Laboratory of the Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
World Neurosurg. 2024 Apr;184:293-302.e11. doi: 10.1016/j.wneu.2024.01.054. Epub 2024 Jan 14.
Malignant peripheral nerve sheath tumors (MPNSTs) are rare yet highly aggressive soft tissue sarcomas of mesenchymal origin, characterized by a heterogeneous pathological spectrum, limited therapeutic options, and high metastatic potential.
Here, the authors conducted a comprehensive bibliometric analysis of the 100 most-cited MPNST articles by utilizing Elsevier's Scopus to identify all relevant published and indexed articles referring to MPNST, thereby aiming to elucidate the pertinent research findings regarding the disease's pathophysiology and therapeutic advancements. Articles were classified as basic science or clinical and analyzed for various bibliometric parameters.
The majority of articles (75%) focused on clinical aspects, reflecting the extensive clinicopathological characterization of MPNSTs. Notable studies investigated prognostic factors, histological and immunohistochemical features, and diagnostic modalities. The identification of loss of function mutations in the polycomb repressive complex 2 emerged as a pivotal role, as it opened avenues for potential targets for novel therapeutic interventions. Newer articles (published in or after 2006) demonstrated higher citation rates, suggesting evolving impact and collaboration.
This bibliometric analysis showed how developments in the understanding of MPNST pathophysiology and the creation of novel therapeutic strategies occurred throughout time. Changes that have been noticed recently could portend future innovative therapeutic approaches.
恶性外周神经鞘瘤（MPNST）是一种罕见但高度侵袭性的间叶来源的软组织肉瘤，具有异质性的病理谱、有限的治疗选择和高转移潜能。
作者利用爱思唯尔的 Scopus 对 100 篇最具引用价值的 MPNST 文章进行了全面的文献计量分析，以确定所有与 MPNST 相关的已发表和索引文章，从而阐明关于该疾病病理生理学和治疗进展的相关研究结果。文章分为基础科学或临床，并对各种文献计量参数进行了分析。
大多数文章（75%）侧重于临床方面，反映了 MPNST 的广泛临床病理特征。值得注意的研究调查了预后因素、组织学和免疫组织化学特征以及诊断方法。多梳抑制复合物 2 功能丧失突变的鉴定成为一个关键作用，因为它为新的治疗干预的潜在目标开辟了道路。较新的文章（发表于或之后 2006 年）显示出更高的引用率，表明影响力和合作在不断发展。
这项文献计量分析表明，人们对 MPNST 病理生理学的理解和新的治疗策略的发展是如何随时间推移而发生的。最近注意到的变化可能预示着未来创新的治疗方法。
