Zhao Hui, Fang Lanlan, Chen Yuting, Ni Jianping, Chen Xuyang, Pan Faming
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
J Affect Disord. 2024 Apr 1;350:319-327. doi: 10.1016/j.jad.2024.01.111. Epub 2024 Jan 12.
Polycyclic aromatic hydrocarbons (PAHs) are prevalent organic pollutants in the environment; however, limited research has been conducted to explore their potential effects on sleep disorders. This study aims to investigate the relationship between single and mixed PAHs exposures and sleep disorders.
This study analyzed National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2016, involving 7730 adult participants. To examine the relationship between PAHs exposure and sleep disorders, we employed survey-weighted multivariate logistic regression models and restricted cubic spline (RCS) models to evaluate single PAHs exposure. Additionally, we employed three mixed-exposure models to examine the relationship between combined PAHs exposure and sleep disorders.
After adjusting for covariates, our analyses revealed positive associations between several urinary PAHs metabolites (1-hydroxynaphthalene (1-NAP), 2-NAP, 3-hydroxyfluorene (3-FLU), 2-FLU, and 1-hydroxypyrene (1-PYR)) and sleep disturbance. Consistency across various analytical methods underscores a discernible positive correlation between simultaneous exposure to PAHs and sleep disorders. This association is predominantly influenced by the presence of NAP and FLU. Remarkably, a positive relationship between combined PAHs exposure and sleep disorders emerged within the younger and middle-aged demographic but did not manifest within the elderly population.
In conclusion, our study provides new epidemiological evidence suggesting that both single and mixed PAHs exposures may increase the risk of sleep disorders. Further prospective investigations are necessary to validate these findings.
多环芳烃（PAHs）是环境中普遍存在的有机污染物；然而，关于其对睡眠障碍潜在影响的研究有限。本研究旨在探讨单一和混合PAHs暴露与睡眠障碍之间的关系。
本研究分析了2005年至2016年美国国家健康与营养检查调查（NHANES）的数据，涉及7730名成年参与者。为了研究PAHs暴露与睡眠障碍之间的关系，我们采用调查加权多元逻辑回归模型和受限立方样条（RCS）模型来评估单一PAHs暴露。此外，我们采用三种混合暴露模型来研究PAHs联合暴露与睡眠障碍之间的关系。
在调整协变量后，我们的分析显示几种尿PAHs代谢物（1-羟基萘（1-NAP）、2-NAP、3-羟基芴（3-FLU）、2-FLU和1-羟基芘（1-PYR））与睡眠障碍之间存在正相关。各种分析方法的一致性强调了PAHs同时暴露与睡眠障碍之间明显的正相关。这种关联主要受NAP和FLU的影响。值得注意的是，PAHs联合暴露与睡眠障碍之间的正相关在年轻和中年人群中出现，但在老年人群中未表现出来。
总之，我们的研究提供了新的流行病学证据，表明单一和混合PAHs暴露都可能增加睡眠障碍的风险。需要进一步的前瞻性研究来验证这些发现。
